Plasma Separation
Plasma Separation - Related Videos
04:21
Exosome Isolation: A Technique to Separate Exosomes from the Plasma of Non-small Cell Lung Cancer Patients
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2023
The plasma-isolated exosomes can be used as a non-invasive and repeatable way for the detection and follow-up of the biomarkers for early detection and disease progression. This video describes the protocol for the separation of exosomes from the plasma samples of non-small cell lung cancer patients, which could be used for DNA and protein extractions.
08:42
How to Ignite an Atmospheric Pressure Microwave Plasma Torch without Any Additional Igniters
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Cited by 26 •
2015
This movie shows how an atmospheric plasma torch can be ignited by microwaves with no additional igniters and provides a stable and continuous plasma operation suitable for plenty of applications.
08:36
An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation
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Cited by 20 •
2016
An experimental setup was created for the helium-operated kHz frequency plasma jet. The setup includes a cage for the plasma power supply and jet and an in-house built reactor to monitor plasma-induced reactive species without the interference of the ambient atmosphere.
06:46
Applying X-ray Imaging Crystal Spectroscopy for Use as a High Temperature Plasma Diagnostic
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Cited by 4 •
2016
X-ray spectra provide a wealth of information on high temperature plasmas. This manuscript presents the operation of a high wavelength resolution spatially imaging X-ray spectrometer used to view hydrogen- and helium-like ions of medium atomic number elements in a tokamak plasma.
07:37
Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
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Cited by 66 •
2017
A high-throughput cold physical plasma treatment protocol of liquids and cells is shown. It involves setting up different feed gas compositions for plasma ignition, measuring the plasma's emission spectra, and the subsequent analysis of liquids and cellular activity after plasma treatment.
FAQs
Centrifugation separates blood components according to density. Under centrifugal force, the cellular components and liquid portion distribute into distinct fractions, allowing the plasma layer to be recovered separately. This physical separation is useful when laboratory testing requires access to soluble substances without the cellular fraction, supporting biochemical analysis and clinical assessment.
Membrane filtration relies on pore size rather than density. The membrane retains blood cells while allowing plasma to pass through, producing a cell-reduced liquid fraction. This mechanism differs from centrifugation and can be selected when a separation process based on selective passage through a barrier is appropriate for laboratory or therapeutic handling.
Separated plasma contains water, electrolytes, proteins, clotting factors, hormones, and other soluble substances. These constituents provide measurable biochemical information about the body and support clinical assessment. Preserving access to this liquid fraction helps diagnostic assays evaluate circulating substances without relying on the cellular components of blood.
The two approaches use different physical principles. Centrifugation creates separation through differences in component density, whereas membrane filtration uses pores that retain cells and pass plasma. Both can isolate the liquid fraction, but their distinct mechanisms allow plasma separation to be incorporated into different laboratory, collection, or therapeutic procedures.
A basic workflow applies either centrifugation or membrane filtration to a blood sample or blood stream, separates the cellular fraction from the liquid fraction, and recovers the plasma for its intended use. The resulting material may proceed to biochemical analysis, clinical assessment, transfusion-related collection, or a therapeutic procedure.
Laboratories use separated plasma as the material for diagnostic assays and clinical assessment. Its soluble contents, including proteins, electrolytes, hormones, and clotting factors, can provide information for evaluating circulating biochemical and physiological components. The separation step therefore prepares a suitable fraction for testing rather than analyzing the cellular portion of blood.
In transfusion medicine, plasma separation supports the collection of plasma for transfusion. The process isolates the liquid blood fraction containing soluble components such as proteins and clotting factors. This makes plasma available as a distinct blood product, separate from the cellular components that remain in the original blood mixture.
Plasmapheresis uses plasma separation as part of a therapeutic procedure designed to remove selected circulating substances from a patient’s blood. Separating the plasma creates access to the liquid fraction in which those substances are found. This links the physical separation step to a clinical intervention rather than solely to laboratory testing or collection.