Coronary Artery Occlusion
Coronary Artery Occlusion - Related Videos
13:10
Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)
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Cited by 7 •
2017
Surgical correction of ALCAPA is highly recommended, regardless of age or the degree of intercoronary collateralization. This protocol presents a technique for the direct re-implantation of adult-type ALCAPA into the aorta to re-establish the dual-coronary perfusion. Whenever feasible, direct re-implantation is preferred to other surgical correction techniques.
05:47
Modified Technique for Coronary Artery Ligation in Mice
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Cited by 8 •
2013
The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.
08:30
Use of a Hanging Weight System for Coronary Artery Occlusion in Mice
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Cited by 21 •
2011
A murine model for myocardial ischemia and ischemic preconditioning is an important tool study cardioprotective mechanisms in vivo. Here, we report an easy applicable in situ model for cardiac IP using a hanging-weight system for coronary artery occlusion.
06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Cited by 20 •
2015
Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.
07:41
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
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Cited by 47 •
2011
Numerous genetic manipulations and/or intramyocardial injections of genes, proteins, cells, and/or biomaterials are superimposed upon the dimension of time in studies of acute ischemia/ reperfusion injury and chronic remodeling in mice. This video illustrates the microsurgical procedures for ischemia/reperfusion, permanent coronary artery ligation, and intramyocardial injection studies.
FAQs
Atherosclerotic plaque gradually narrows the arterial wall, reducing the space available for blood flow. If the plaque ruptures, it can trigger thrombus formation, creating a clot that may suddenly obstruct downstream perfusion. This transition from chronic narrowing to abrupt blockage explains why symptoms can develop rapidly and why plaque disruption is clinically important.
The degree of obstruction determines how much blood and oxygen reach the downstream heart muscle. A partial blockage may produce ischemia and angina, whereas a more severe or complete obstruction can cause prolonged oxygen deprivation. When ischemia persists, myocardial infarction may occur, resulting in permanent injury to the affected tissue.
Both conditions reflect inadequate oxygen delivery to cardiac muscle, but their outcomes differ. Ischemia associated with an occlusion can produce angina, while prolonged or severe obstruction may progress to myocardial infarction. This distinction matters because infarction indicates permanent tissue injury and therefore represents a more serious consequence of impaired coronary perfusion.
Assessment combines risk evaluation with electrocardiographic and imaging-based diagnosis. Risk assessment helps identify patients more likely to have clinically important disease, while electrocardiography evaluates the heart’s electrical response to impaired perfusion. Imaging provides additional information about the coronary circulation and supports recognition of obstruction and its effects on the myocardium.
Management may include antiplatelet therapy, thrombolysis, angioplasty, or stent placement. These approaches address the occlusion through different strategies: medication can limit clot-related obstruction, thrombolysis can target an existing thrombus, and angioplasty or stenting can reopen or support the narrowed arterial passage. Treatment selection is part of clinical management of ischemic heart disease.
It is central to evaluating ischemic heart disease because the process links arterial plaque, thrombus formation, reduced myocardial perfusion, and tissue injury. Clinicians use this framework to connect symptoms such as angina with diagnostic findings, assess the potential severity of obstruction, and consider interventions intended to limit or reverse its cardiovascular consequences.