Arcuate Fasciculus

The arcuate fasciculus is a major white matter fiber pathway that connects language-related regions in the frontal and temporal lobes, making it central to speech, language comprehension, and repetition. Its bundled axons form part of the brain’s dorsal language network, transmitting information between auditory processing areas near Wernicke’s region and speech-planning areas near Broca’s region. Neuroscience studies use diffusion tensor imaging and tractography to examine its structure, development, and organization, while clinical research links damage to the pathway with conduction aphasia and impaired repetition. Mapping the arcuate fasciculus also supports research on language lateralization, neurodevelopment, and planning for brain surgery.

Arcuate Fasciculus - Related Videos

Research

JoVE Journal - Neuroscience

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

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Cited by 2 •

2017

This paper demonstrates the effective use of a fiber dissection method to reveal the superficial white matter tracts and periventricular structures of the human brain, in three-dimensional space, to aid student comprehension of ventricular morphology.

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

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2025

This article presents a step-by-step protocol for the isolation and functional evaluation of human renal arterial branches, facilitating preclinical studies for pharmaceutical development.

Conditional Genetic Transsynaptic Tracing in the Embryonic Mouse Brain

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Cited by 5 •

2014

Capitalizing on a binary genetic strategy we provide a detailed protocol for neural circuit tracing in mice that express complementary transsynaptic tracers after Cre-mediated recombination. Because cell-specific tracer production is genetically encoded, our experimental approach is suitable to study the formation and maturation of neural circuitry during murine embryonic brain development at a single cell resolution.

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

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Cited by 32 •

2017

The purpose of this study is to show each step of the fiber dissection technique on human cadaveric brains, the 3D documentation of these dissections, and the diffusion tensor imaging of the anatomically dissected fiber pathways.

Education

JoVE Science Education - Psychology

Using Diffusion Tensor Imaging in Traumatic Brain Injury

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2023

Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California Traditional brain imaging techniques using MRI are very good at visualizing the gross structures of the brain. A structural brain image made with MRI provides high contrast of the borders between gray and white matter, and information about the size and shape of brain structures. However, these images do not detail the underlying structure and integrity of white matter networks in the brain, which...

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