Ultrasound Sonication
Ultrasound Sonication - Related Videos
03:22
Low Frequency Ultrasound Application: A Method to Determine the Effect of Sonication on Human Leukemia Cells
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2023
This video describes the selective damage of human leukemia cells by using low frequency ultrasound. This application of low frequency ultrasound in a preclinical in vitro condition demonstrates that cell destruction can be attained in order to examine and compare the effects of sonication on leukemia and normal cells.
09:05
Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells
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2015
Selective damage of human leukemia cells can be achieved through a novel approach of applying low frequency ultrasound both with and without chemotherapeutic pretreatment of leukemic and normal hematopoietic cells.
07:24
Sonication Extraction of Lipid Biomarkers from Sediment
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2023
Source: Laboratory of Jeff Salacup - University of Massachusetts Amherst The material comprising the living "organic" share of any ecosystem (leaves, fungi, bark, tissue; Figure 1) differs fundamentally from the material of the non-living "inorganic" share (rocks and their constituent minerals, oxygen, water, metals). Organic material contains carbon linked to a series of other carbon and hydrogen molecules (Figure 2), which distinguishes it from inorganic material. Carbon's wide valency range...
02:56
Ultrasound-Induced Neuromodulation Using a Microelectrode Array System
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2025
This video demonstrates the method for inducing the modulation of neural activity in cultured human iPSC-derived neurons in a multi-well microelectrode array, or MEA system using a focused ultrasound transducer.
09:00
Murine Echocardiography and Ultrasound Imaging
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Cited by 61 •
2010
This video demonstrates use of a rail-mounted high-frequency ultrasound probe to perform echocardiography on an anesthetized mouse. The methods describe both conventional two-dimensional and M-mode measurements of cardiac function in addition to newer, more powerful tools such as color Doppler, strain analysis, as well as general and targeted contrast imaging.
FAQs
These parameters determine how acoustic energy is delivered and therefore influence the resulting mechanical effects in tissue. Frequency describes the sound-wave characteristics, intensity reflects the strength of delivery, and pulse duration determines how long the tissue experiences stimulation. Adjusting them helps researchers investigate different neural responses while accounting for the selected brain target.
Focusing concentrates acoustic energy on a selected brain region rather than distributing it broadly. This targeting can improve spatial precision, allowing researchers to examine the contribution of particular regions to neural circuits, sensory processing, or behavior. The intended response still depends on the acoustic settings and targeting conditions used during the experiment.
Ultrasound sonication can provide access to brain stimulation without implanted electrodes, making it useful for investigating neural function through externally delivered mechanical energy. This distinction is important when researchers want to study circuit activity or behavioral effects while avoiding an implanted interface. Focused delivery further supports experiments that require stimulation of a selected brain region.
A study generally begins by identifying the brain region or neural function of interest, then selecting the acoustic conditions, including frequency, intensity, and pulse duration. Researchers also establish the targeting approach so delivery is focused appropriately. The resulting neural, sensory, or behavioral response can then be examined in relation to those controlled stimulation conditions.
Researchers may choose this approach when they need to examine how a targeted brain region contributes to neural circuits, sensory function, or behavior. Focused stimulation allows the experimental condition to emphasize a specific location, while changes in acoustic parameters provide additional control over the delivered mechanical energy. These features support investigations of brain function without implanted electrodes.
In therapeutic neuromodulation research, ultrasound sonication provides a way to investigate interventions that influence brain activity without requiring implanted electrodes. Its focused delivery is relevant when spatial precision matters, because researchers can examine whether targeting particular regions produces useful neural effects. The same framework also supports studies of other brain-directed interventions requiring noninvasive access.