Animal Model Endometriosis
Animal Model Endometriosis - Related Videos
08:02
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
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Cited by 62 •
2012
A description of the surgical induction of endometriosis in mice and rats by auto-transplantation of uterine tissue to the arterial cascade of the intestinal mesentery.
26:43
Computer-Generated Animal Model Stimuli
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Cited by 8 •
2007
Computer-generated stimuli using the Jacky dragon as a model.
07:20
Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
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Cited by 21 •
2012
Loss of peritoneal integrity provides a new paradigm to understand and treat chronic pelvic pain in women with mild forms of endometriosis and can be easily detected using intraoperative instillation of dye at the time of laparoscopy.
07:12
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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Cited by 2 •
2020
Many rodent models of endometriosis are limited by technical complexity, reproducibility, and/or need for immunocompromised animals or special reporter mice. We present a simplified system of lesion induction using any experimental mouse with an independently verifiable, objective scoring system and with no requirement for ovariectomy or survival surgery.
09:45
An Isolated Working Heart System for Large Animal Models
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Cited by 22 •
2014
Most studies involving the Langendorff apparatus use small animal models due to the increased complexity of systems for larger mammals. We describe a Langendorff system for large animal models that allows for use across a range of species, including humans, and relatively easy data acquisition.
FAQs
Ovarian hormones support the growth of uterine tissue implanted outside the uterus, making hormonal status an important influence on lesion development. This dependence allows researchers to examine how endocrine conditions relate to ectopic tissue behavior and provides a biological basis for evaluating hormonal treatments. Hormone-supported growth also helps explain why experimental outcomes can vary with the model’s reproductive context.
Researchers can examine several linked responses, including local inflammation, new blood-vessel formation, immune activity, and pain-related behaviors. Together, these outcomes extend analysis beyond lesion presence alone and help connect abnormal tissue growth with symptoms and surrounding biological changes. The model therefore supports studies of how inflammatory, angiogenic, and immune processes may contribute to disease progression.
Rodent models reproduce selected features of endometriosis, but their menstrual biology differs from that of humans. Consequently, lesion growth, inflammatory responses, treatment effects, or pain-related findings may not translate directly to patients. Researchers must distinguish what the model demonstrates experimentally from what remains uncertain in human disease, especially when drawing conclusions about mechanisms or clinical benefit.
A commonly used workflow implants uterine tissue into the peritoneal cavity of a rodent and then examines the resulting ectopic tissue under conditions in which ovarian hormones support growth. Investigators can subsequently evaluate lesion development and associated responses, such as inflammation, angiogenesis, immune activity, or pain behaviors. The exact findings depend on the biological outcome being studied.
After ectopic lesions develop, investigators can use the system to study treatment categories directed at different disease features. Hormonal approaches address hormone-supported growth, anti-inflammatory approaches target local inflammation, and anti-angiogenic approaches address blood-vessel formation. Comparing these interventions with lesion, biological, or behavioral outcomes helps researchers assess which disease processes are affected.
These models can support investigations of treatment effects on fertility and pelvic pain as well as on ectopic tissue and local disease responses. Pain behaviors provide an experimental link to a major symptom, while fertility-related assessments address reproductive consequences. Such outcomes broaden the model’s medical relevance by connecting biological mechanisms with functional effects important in patients.