Patient Donor Selection
Patient Donor Selection - Related Videos
11:59
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
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Cited by 2 •
2017
Quantification of donor-derived cells is required to monitor engraftment after stem cell transplantation in patients with hemoglobinopathies. A combination of flow cytometry-based cell sorting, colony formation assay, and subsequent analysis of short tandem repeats may be used to assess the proliferation and differentiation of progenitors in the erythroid compartment.
07:17
Single Port Donor Nephrectomy
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Cited by 5 •
2011
Single port laparoscopic surgery is changing the standard of care in surgical care like nothing since the laparoscopic technique was introduced 20 years ago. We present out technique of single port donor nephrectomy using the Gelpoint device. We have successfully performed this surgery in 100 patients.
08:37
Corneal Donor Tissue Preparation for Endothelial Keratoplasty
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Cited by 31 •
2012
Endothelial corneal transplantation is a surgical technique for treatment of posterior corneal diseases. Mechanical microkeratome dissection to prepare tissue results in thinner, more symmetric grafts with less endothelial cell loss and improved outcomes. Dissections can be performed at the eye bank prior to corneal transplantation surgery.
12:52
Conjugation: A Method to Transfer Ampicillin Resistance from Donor to Recipient E. coli
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2023
Source: Alexander S. Gold1, Tonya M. Colpitts1 1 Department of Microbiology, Boston University School of Medicine, National Emerging Infections Diseases Laboratories, Boston, MA First discovered by Lederberg and Tatum in 1946, conjugation is a form of horizontal gene transfer between bacteria that relies on direct physical contact between two bacterial cells (1). Unlike other forms of gene transfer, such as transformation or transduction, conjugation is a naturally occurring process in which...
12:13
Ex Situ Normothermic Machine Perfusion of Donor Livers
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Cited by 21 •
2015
Here we present a protocol describing oxygenated ex situ machine perfusion of donor liver grafts. This article contains a step by step protocol to procure and prepare the liver graft for machine perfusion, prepare the perfusion fluid, prime the perfusion machine and perform oxygenated normothermic machine perfusion of the liver graft.
FAQs
Blood group and tissue markers provide different compatibility information, so assessing both gives clinicians a broader basis for comparison among potential donors. These findings are considered alongside the planned procedure and the patient’s need. Using more than one biological factor helps reduce the likelihood of immune-mediated complications and supports a more informed selection decision.
Donor health assessment helps determine whether a potential donor is suitable before donation proceeds. Screening for infectious diseases addresses the risk of transmitting infection, while broader eligibility assessment contributes to evaluating procedural safety and expected treatment benefit. Together, these checks help clinicians avoid preventable hazards and select a donor whose contribution is appropriate for the patient’s treatment.
Selection is not based on compatibility information alone. Clinicians also weigh how urgently the patient needs treatment, the benefit expected from each option, and the risks associated with the procedure. This balance becomes especially important when several donors appear possible but differ in biological suitability or in the practical risks linked to using their donated blood, cells, tissue, or organ.
The donated material and planned procedure determine which considerations are most relevant. Blood donation emphasizes blood group and infectious disease screening, whereas transplantation and cellular therapies also place importance on tissue markers, donor health, urgency, expected benefit, and procedural risk. Consequently, Patient Donor Selection must be adapted to the type of donation rather than applied as a single identical checklist.
A structured evaluation begins with donor health and eligibility assessment, followed by compatibility testing suited to the planned procedure. Clinicians consider blood group, tissue markers, and infectious disease screening, then compare the resulting information with treatment urgency, expected benefit, and procedural risk. The final choice integrates these findings to identify the most suitable available option for the patient.
Structured evaluation is particularly important when selecting donors for transplantation or cellular therapies, where clinicians may need to balance several competing considerations. It helps organize biological compatibility findings with urgency, expected benefit, and procedural risk. The same principles also support safer decisions for donated blood or tissue by reducing avoidable infection and immune-related concerns while promoting equitable care.