Rodent Disease Models
Rodent Disease Models - Related Videos
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Cited by 14 •
2015
The use of ultra-high field MRI as a non-invasive way to obtain phenotypic information of rodent models for polycystic kidney disease and to monitor interventions is described. Compared with the traditional histological approach, MRI images can be acquired in vivo, allowing for longitudinal follow-up.
08:43
Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
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Cited by 26 •
2015
Here we demonstrate the use of a wireless enabling technology for electroencephalogram (EEG) in neonatal rodent models of human disease. With telemetry, there are no encumbering connections, thus allowing natural behaviors.
11:51
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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Cited by 42 •
2010
Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.
09:40
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
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Cited by 35 •
2016
Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.
10:29
Principles of Rodent Surgery for the New Surgeon
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Cited by 56 •
2011
Before attempting surgery, a new surgeon should have training in basic surgical techniques and concepts. This article will present basic surgical considerations with an emphasis on rodents.
FAQs
Model selection should begin with the human disease feature the study needs to reproduce, such as a physiological change, behavioral alteration, tissue abnormality, or molecular pathway. Researchers then consider whether genetic modification, selective breeding, transplantation, infection, or controlled exposure best represents that feature. A suitable model improves interpretability, while a poor match can limit the relevance of later findings.
The method used to establish a model shapes which aspects of disease biology become visible. Genetic modification or selective breeding can emphasize inherited influences, whereas transplantation, infection, or controlled exposure can reproduce other disease-causing conditions. Because each approach represents only selected features of human disease, researchers must connect the creation method to the biological question being investigated.
Molecular pathways and tissue changes can reveal biological processes that are not evident from physiology or behavior alone. Measuring these levels alongside broader changes helps researchers connect a disease feature with its underlying biology and identify possible therapeutic targets. Using several types of evidence also supports a more complete assessment of whether the model reflects the intended human pathology.
Species-specific differences can affect how disease features appear and how biological pathways respond, even when a model reproduces an important aspect of human pathology. Consequently, results require careful interpretation rather than automatic clinical application. Researchers should evaluate how faithfully the selected model represents the relevant human disease before using its findings to guide therapy development or clinical study design.
A study generally begins by selecting or creating a model that represents the disease feature of interest. Researchers then assess relevant physiology, behavior, tissues, and molecular pathways, comparing the observed changes with the intended human pathology. The resulting evidence can be used to investigate disease biology, evaluate candidate interventions, or determine whether further study is justified.
After a model reproduces relevant disease features, researchers can examine whether an intervention changes the associated physiology, behavior, tissue state, or molecular pathways. These observations help assess therapeutic efficacy and may expose safety concerns before clinical investigation. The findings can also identify therapeutic targets and contribute to the design of clinical studies, while model limitations remain important when interpreting results.