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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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JoVE Journal Medicine
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

DOI:
10.3791/52757-v

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07:35 min

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June 23, 2015

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, , ,
1Department of Internal Medicine, Division of Nephrology,Mayo Clinic, 2Department of Biochemistry and Molecular Biology,Mayo Clinic

Chapters

  • 00:05Title
  • 01:40Scanner Configuration and Animal Preparation
  • 02:56MRI Experiment
  • 05:24Results: Structural Changes in a Mouse Model of Polycystic Kidney Disease Shown with Ultra-high Field MRI
  • 06:51Conclusion

Summary

Automatic Translation

Automatic Translation

The use of ultra-high field MRI as a non-invasive way to obtain phenotypic information of rodent models for polycystic kidney disease and to monitor interventions is described. Compared with the traditional histological approach, MRI images can be acquired in vivo, allowing for longitudinal follow-up.

Tags

Keywords: Polycystic Kidney DiseasePKDRodent ModelsUltra-high Field MRIIn Vivo ImagingLongitudinal StudiesTotal Kidney VolumeTKVNon-invasive ImagingPre-clinical StudiesDrug Monitoring

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