Offspring Resilience
Offspring Resilience - Related Videos
09:09
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
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Cited by 4 •
2022
Maternal infection is a risk factor for neurodevelopmental disorders. Mouse models of maternal immune activation (MIA) may elucidate infection's impact on brain development and function. Here, general guidelines and a procedure are provided to produce reliably resilient and susceptible offspring exposed to MIA.
12:22
Mindfulness in Motion (MIM): An Onsite Mindfulness Based Intervention (MBI) for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement
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Cited by 105 •
2015
The Mindfulness in Motion (MIM) protocol offers a pragmatic Mindfulness Based Intervention (MBI) on-site, for persons working in chronically high-stress work environments that significantly increases resiliency and work engagement. The protocol has proven feasible, beneficial, and is easily adaptable to other high-stress workplaces.
06:11
Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
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Cited by 2 •
2024
Here, we present a protocol to establish an intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) mouse model, allowing us to observe age-related changes in glucose metabolism that may be attributed to ICSI, providing insights into its potential long-term impacts on human development.
05:45
Assessing Disaster Resilience of Concrete with Titanium Dioxide Nanoparticles
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2025
This protocol describes the assessment of whether applying titanium dioxide to concrete enhances its physical properties, thereby increasing its resistance to the effects of natural disasters caused by extreme events.
03:19
Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
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2024
This protocol describes the method for reducing dietary intake of folic acid or choline in female mice prior to pregnancy with the objective of investigating the impact of maternal diet on offspring health outcomes.
FAQs
Glucocorticoid signaling links stress-regulation systems with brain development. These signals can shape how developing neural systems respond to biological or environmental challenges, while their effects interact with parental care and the broader social environment. Studying this relationship helps explain why early-life conditions may support adaptive responses in some individuals yet contribute to later stress-related vulnerability in others.
Parental care and social conditions provide important developmental experiences that interact with biological stress systems. Their influence can affect how young individuals regulate responses to adversity as neural circuits mature. In neuroscience research, examining these relationships clarifies why similar early-life stressors may be associated with different patterns of emotional regulation, learning, and behavior across development.
Experience-dependent changes allow developing neural circuits to be shaped by conditions encountered during growth. This plasticity provides a mechanism through which early experiences can influence later emotional regulation, learning, and behavior. It also explains why developmental context matters when interpreting resilience, because biological stress signaling, caregiving, and social experiences may jointly alter how neural systems respond to future challenges.
Research commonly examines emotional regulation, learning, and behavior as outcomes that may reveal how early-life conditions affect development. These outcomes are considered across developmental stages rather than at only one time point. Comparing patterns over time can help identify adaptive responses, persistent difficulties, and possible links between early adversity and vulnerability to stress-related disorders.
A developmental approach relates early-life conditions to later changes in brain-related processes and behavior. Researchers consider stress-regulation systems, glucocorticoid signaling, brain maturation, parental care, and social experience together rather than treating any single factor as sufficient. This framework supports interpretation of how young individuals maintain healthy development, adapt to adversity, or show emerging stress-related difficulties.
By identifying interactions among stress systems, neural development, caregiving, and social context, this research can clarify factors associated with healthier developmental outcomes. The findings may guide strategies intended to support emotional regulation, learning, and behavior in children and other developing organisms. They also provide scientific context for understanding and potentially reducing vulnerability to stress-related disorders.