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En tredimensionel spheroid model til at undersøge tumor-stromal interaktion i hepatocellulær karcinom
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En tredimensionel spheroid model til at undersøge tumor-stromal interaktion i hepatocellulær karcinom

Article DOI: 10.3791/62868-v • 12:24 min • September 30th, 2021
September 30th, 2021 •
*1,2, *2, 2, 2, *3, *4,5
1Department of Biochemistry, Faculty of Pharmacy, Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust
* These authors contributed equally

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Omfattende in vitro-modeller , der trofast generobrer den relevante menneskelige sygdom, mangler. Den nuværende undersøgelse præsenterer tre-dimensionelle (3D) tumor spheroid skabelse og kultur, en pålidelig in vitro værktøj til at studere tumor-stromal interaktion i human hepatocellulær karcinom.

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