Microbubble Nanoparticle
Microbubble Nanoparticle - Related Videos
06:10
Injection of Microbubbles into Isolated Mouse Embryos: A Technique to Deliver Microbubble Contrast Agents into the Vasculature of Living Murine Embryos
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2025
This video demonstrates a procedure to inject microbubble contrast agents into an isolated late gestation stage mouse embryo. The microbubble contrast agent-based ultrasound imaging helps visualize and characterize the vascular environment of the embryo.
12:00
Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
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Cited by 2 •
2016
This protocol describes a simple preparation method for gold nanoparticle integrated photo-responsive liposomes with the commercially available materials. It also shows how to measure the microbubble cavitation process of the synthesized liposomes upon the treatment of pulsed laser.
08:24
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
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Cited by 19 •
2011
Ultrasound Targeted Microbubble Destruction (UTMD) can be used to direct site-specific delivery of bioactive molecules, including therapeutic genes, to target organs accessible to ultrasound, such as the heart and liver1-6.
01:28
Focused Ultrasound-Enhanced Nanoparticle Delivery in a Mouse Model for Tumor Therapy
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2025
Begin with an anesthetized tumor-bearing mouse and shave its head.Place it in an MRI scanner integrated with the focused ultrasound system.The initial MRI scan locates the brain tumor and nearby blood vessels.Inject a contrast agent intravenously, then administer fluorescently labeled nanoparticles coated onto gas-filled microbubbles.The contrast agent and microbubbles circulate and reach the brain.Apply focused ultrasound waves to the tumor site.The ultrasound causes the microbubbles to expand...
14:10
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Cited by 15 •
2010
Insonation of microbubbles is a promising strategy for tumor ablation at reduced time-averaged acoustic powers, as well as for the targeted delivery of therapeutics. The purpose of the present study is to develop low duty cycle ultrasound pulsing strategies and nanocarriers to maximize non-thermal microvascular ablation and payload delivery to subcutaneous C6 gliomas.
FAQs
Shell composition helps determine how the particles stabilize their gas core and interact with biological environments. Lipid, polymer, and protein shells can also serve as carriers for drugs, genes, or imaging agents. Selecting among these materials allows bioengineers to connect particle stability and payload transport with the intended diagnostic or therapeutic use.
Ultrasound causes the gas-filled particles to oscillate, producing a mechanical response that can alter nearby biological interfaces. Under suitable exposure, this response may increase local permeability or lead to controlled cavitation. These effects provide a way to stimulate transport or release at a selected tissue rather than relying only on passive distribution.
The combination links the transport advantages of nanoscale materials with the externally triggered behavior of microbubbles. Ultrasound supplies a controllable stimulus, while the shell can carry functional payloads. Together, these features support localized action, which may improve treatment placement and reduce exposure of tissues outside the selected target region.
Design begins by matching a shell material with the intended payload, such as a drug, gene, or imaging agent. The system then incorporates the gas-filled structure and an ultrasound response suited to localized oscillation, permeability change, or controlled cavitation. This coordinated design connects particle composition, acoustic behavior, and the desired biological outcome.
The platform supports several bioengineering applications, including targeted drug delivery, gene delivery, molecular imaging, and stimulus-responsive release. A single particle design may combine diagnostic and therapeutic functions by carrying an imaging agent alongside a treatment payload. This multifunctionality makes the approach relevant to systems that need both biological localization and externally controlled activity.
These systems can support molecular imaging while also enabling localized delivery or release, allowing diagnostic and therapeutic roles to operate within the same platform. Their acoustic response provides a means of interacting with selected tissues, whereas their nanoscale carriers transport functional agents. The resulting approach is relevant to efforts to improve treatment localization and limit systemic exposure.