Needle Array Electrodes

Needle array electrodes are devices composed of multiple needle-shaped conductive elements that record or deliver electrical signals at closely spaced locations within or against biological tissue. Their sharp, three-dimensional geometry improves tissue contact and enables localized measurement or stimulation, while the array arrangement captures spatial patterns of electrical activity across a region. In cancer research, these electrodes can help characterize tumor-associated electrical properties, monitor cellular responses, and apply localized electric fields for studies of electroporation and treatment response. By linking electrical behavior with tumor structure and function, needle array electrodes support more precise investigation of cancer biology and emerging therapeutic strategies.

Needle Array Electrodes - Related Videos

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JoVE EoE - Neurophysiology

Implanting an Electrode Array and Optic Fiber into the Mouse Hippocampus

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2025

This video demonstrates the stereotactic implantation of a wire electrode array and an optic fiber in the hippocampus of a mouse model.

Research

JoVE Journal - Neuroscience
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Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

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Cited by 28 •

2011

A robust way to study neuronal avalanches, i.e. scale-invariant spatio-temporal activity bursts, indicative of critical state dynamics in cortex. Avalanches emerge spontaneously in developing superficial layers of cultured cortex which allows for long-term measurements of the activity with planar integrated multi-electrode arrays (MEA) under precisely controlled conditions.

Constructing Patterned Neuronal Circuits on a Multi-Electrode Array

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2025

This video demonstrates the process of culturing neuronal cells on a patterned multi-electrode array (MEA) to establish modular neuronal networks. This method allows the study of neural signal transmission and cellular interactions.

Research

JoVE Journal - Biology
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How to Culture, Record and Stimulate Neuronal Networks on Micro-electrode Arrays (MEAs)

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Cited by 86 •

2010

This protocol provides the necessary information for setting up, caring for, recording from and electrically stimulating cultures on MEAs. In vitro networks provide a means for asking physiologically relevant questions at the network and cellular levels leading to a better understanding of brain function and dysfunction.

Studying the Regeneration of Functional Connections between Spinal Cord Slices Using a Multi-Electrode Array

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2025

The video demonstrates the functional regeneration of propriospinal connections using a multi-electrode array (MEA)-based assay. The spinal cord slices are placed on the MEA and are allowed to fuse. The fused slices are mechanically separated by creating a lesion, inducing propriospinal neurons to grow over the lesion and connect the slices. The electrical activity of the slices is assessed to identify the regeneration of functional connections.

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