Cell Surface
Cell Surface - Related Videos
08:49
Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
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Cited by 8 •
2020
This manuscript describes a genome-scale cell-based screening approach to identify extracellular receptor-ligand interactions.
01:21
Cell-surface Signaling
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2019
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects. Variety of Receptor Families
09:13
Cell-surface Biotinylation Assay
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2023
A cell can regulate the amount of particular proteins on its cell membrane through endocytosis, following which cell surface proteins are effectively sequestered in the cytoplasm. Once within a cell, these surface proteins can be either destroyed or “recycled” back to the membrane. The cell surface biotinylation assay provides researchers with a way to study these phenomena. The technique makes use of a derivative of the small molecule biotin, which can label surface proteins and then be...
06:31
"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome
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Cited by 3 •
2023
Here, we describe a proteomics workflow for characterization of the cell surface proteome of various cell types. This workflow includes cell surface protein enrichment, subsequent sample preparation, analysis using an LC-MS/MS platform, and data processing with specialized software.
10:11
Glycopeptide Capture for Cell Surface Proteomics
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Cited by 8 •
2014
Cell surface proteins are biologically important and widely glycosylated. We introduce here a glycopeptide-capture approach to solubilize, enrich, and deglycosylate these proteins for facile LC-MS based proteomic analyses.
FAQs
Receptors on immune-cell surfaces convert recognition of signaling molecules into coordinated cellular responses. Their binding helps organize activation, allowing cells to respond to external information rather than acting independently. In immunology, this makes receptor-bearing surfaces central to communication between immune cells and to the identification of targets during host defense.
Adhesion molecules and glycoconjugates contribute different but connected recognition functions. Adhesion molecules support attachment between cells or between a cell and its surroundings, whereas glycoconjugates provide carbohydrate-associated surface features involved in identifying what is self or foreign. Together, these elements help immune cells interpret surface cues and establish the physical contacts needed for coordinated responses.
Cell Surface features serve opposing roles in infection. On host cells, particular surface structures can provide pathogens with attachment sites or entry points. On immune cells, the same general class of structures supports target recognition and activation. This dual role makes surface molecules relevant both to how infection begins and to how the host detects and responds to foreign material.
Transport proteins regulate movement across the cell boundary, adding a passage-control function to the signaling roles of receptors. This matters because surface activity is not limited to recognition or adhesion: controlled movement also affects how a cell exchanges substances with its surroundings. In immunology and infection, this provides another surface-level process to consider alongside communication and pathogen contact.
The most informative categories include membrane receptors, adhesion molecules, glycoconjugates, transport proteins, lipids, and associated proteins. Considering these features together helps researchers connect molecular composition with communication, attachment, movement, target identification, and pathogen interaction. This broad view prevents analysis from focusing only on receptors when other surface components also shape cellular behavior.
Cell-surface molecules are relevant to vaccines, antimicrobial therapies, and diagnostics because they sit at key points in immune recognition and infection. Their roles as immune-identification features, pathogen attachment sites, or entry points make them useful targets for intervention and detection. These applications connect basic surface biology with efforts to prevent, treat, or identify infectious processes.
Host–pathogen studies can examine surface-mediated attachment and entry alongside the immune system’s recognition of targets. This approach organizes research around which host or pathogen surface features permit contact and which features enable immune discrimination. The resulting perspective connects molecular interactions at the cell boundary with broader patterns of infection and host defense.