Wounded Ear Model
Wounded Ear Model - Related Videos
08:35
Demonstration of the Rat Ischemic Skin Wound Model
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Cited by 32 •
2015
The rat, due to its size, availability, and rather docile behavior, has been utilized as a research model for many years. The goal of this protocol is to utilize the rat as an ischemic skin wound healing model to provide valuable insight into the pathophysiology of chronic wounds.
12:00
A Simplified Technique for Producing an Ischemic Wound Model
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Cited by 22 •
2012
We have developed a minimally invasive technique to create a rabbit ischemic ear wound model by dividing the central artery and nerve and the cranial neurovascular bundle. A subcutaneous tunnel then cuts all subcutaneous tissues. This procedure causes minimal skin disruption and can be safely used in diabetic animals.
05:39
Murine Model of Wound Healing
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Cited by 207 •
2013
A murine model of cutaneous wound healing that can be used to assess therapeutic compounds in physiological and pathophysiological settings.
09:10
Ear Exam
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video describes the examination of the ear, beginning with a review of its surface and interior anatomy (Figure 1). The cartilaginous auricle consists of the helix, antihelix, earlobe, and tragus. The mastoid process is positioned just behind the earlobe. The slightly curving auditory canal ends at the tympanic membrane, which transmits sound...
07:16
Swine Model of Biofilm Infection and Invisible Wounds
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Cited by 12 •
2023
Chronic wounds that are resistant to antibiotics are a major threat to the healthcare system. Biofilm infections are stubborn and hostile and can cause deficient functional wound closure. We report a clinically relevant swine model of biofilm-infected full-thickness chronic wounds. This model is powerful for mechanistic studies as well as for testing interventions.
FAQs
Barrier disruption exposes tissue to damage-associated danger signals, which initiate local inflammation and promote recruitment of innate immune cells. This early response provides a measurable link between physical injury and host defense. In infection studies, researchers can examine whether microbial exposure changes the magnitude, persistence, or progression of inflammation compared with injury-related signals alone.
The injured site provides a defined anatomical location where researchers can follow both local tissue changes and microbial burden over time. This makes it possible to relate pathogen persistence to leukocyte activity, lesion development, and repair. The model therefore connects the early consequences of barrier damage with later infection outcomes without relying only on systemic measurements.
Lesion development, immune-cell activity, and changes observed over time provide complementary indicators of the tissue response. Increasing inflammatory activity may accompany disease progression, whereas subsequent changes in the injured area can be evaluated in relation to repair. Considering these measurements together helps researchers interpret whether a stimulus primarily sustains inflammation, supports host defense, or affects recovery.
Researchers first create a controlled injury, then introduce microbes or another experimental stimulus when the design requires it. They monitor the local response over a defined period and assess outcomes such as lesion development, microbial burden, and immune-cell activity. This workflow allows injury, exposure, and response measurements to be connected within the same anatomical site.
Three complementary readouts are especially useful: lesion development shows the visible or tissue-level course of the response, microbial burden indicates pathogen persistence or reduction, and immune-cell activity reflects host defense and inflammation. Tracking these outcomes over time helps distinguish changes in tissue condition from changes in microbial control and clarifies how interventions affect disease progression.
The model is useful when an intervention is expected to influence local inflammation, pathogen persistence, leukocyte recruitment, tissue repair, or host defense. Because injury and exposure occur at a defined site, researchers can compare how treatment changes lesion development, microbial burden, or immune-cell activity. These outcomes provide context for judging whether an intervention improves local disease responses.