Contrast Medium Perfusion
Contrast Medium Perfusion - Related Videos
04:31
Assessing Vessel Perfusion via Angiography: A Technique to Introduce Contrast Agent in Descending Aorta to Visualize Blood Vessel Perfusion in Rabbit Model
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2025
This video describes the technique for performing angiography by injecting a contrast agent into the descending aorta to visualize blood vessel perfusion in a rabbit model. This technique helps to understand the perfusion in blood vessels with blockages and after treatment during recovery.
06:02
Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
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Cited by 9 •
2013
The objective of this research is to recreate and then access the anatomy of the human cardiac venous system using 3D reconstructions generated from contrast-computed tomography scans.
06:49
Phase Contrast and Differential Interference Contrast (DIC) Microscopy
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Cited by 26 •
2008
This protocol highlights the principles and practical applications of Phase and Differential Interference Contrast (DIC)...
04:44
Antegrade Perfusion Model: An Ex Vivo Technique to Perfuse Isolated Mouse Heart
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2025
This video describes an antegrade perfusion technique of an isolated mouse heart during which a perfusate is injected through the left ventricle, and eventually, it perfuses the entire myocardium. This method can be used to isolate cardiomyocytes from murine models and generate decellularized hearts for further downstream applications.
10:39
Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
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Cited by 4 •
2015
Here, we present a protocol to inject ultrasound microbubble contrast agents into living, isolated late-gestation stage murine embryos. This method enables the study of perfusion parameters and of vascular molecular markers within the embryo using contrast-enhanced high-frequency ultrasound imaging.
FAQs
The key information comes from how the imaging signal changes over time, not from a single snapshot. As the injected bolus passes through vessels and tissue, X-ray attenuation, magnetic resonance signal, or ultrasound echoes vary. Tracking these changes allows investigators to characterize passage through the circulation and identify differences in vascular behavior.
Time-concentration curves organize the signal changes produced by the passing bolus into a dynamic record. From this record, imaging analysis can derive quantitative measures such as tissue blood volume and flow. These measurements add functional information to structural imaging, helping distinguish differences in vascular supply that anatomy alone may not show.
Across modalities, the measured response is different: X-ray systems track attenuation, magnetic resonance systems track signal, and ultrasound systems track echoes. The common analytical principle is to follow each response during bolus passage. This allows Contrast Medium Perfusion to be adapted to different imaging contexts while preserving its focus on blood-flow-related function.
A study begins with injection of a contrast agent, followed by recording the imaging response as the bolus travels through the circulation. The measurements are collected over time and analyzed to form time-concentration curves. Quantitative outputs, including tissue blood volume and flow, can then be used to assess vascular function in the examined organ or tissue.
In medicine, the approach can support evaluation of cerebral ischemia, myocardial perfusion, tumors, and other conditions involving altered vascular supply. Its value differs by clinical question: cerebral studies can address ischemic blood flow, cardiac studies can focus on myocardial perfusion, and tumor studies can examine vascular characteristics relevant to diagnosis and treatment planning.
Structural images show anatomy, whereas perfusion measurements contribute information about how blood moves through that anatomy. This functional perspective can reveal vascular differences that structural imaging alone may miss. Clinically, the added information can improve diagnosis, inform treatment planning, and help monitor how a condition responds to treatment.