Intestinal Surgery
Intestinal Surgery - Related Videos
10:58
A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids
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Cited by 81 •
2015
In this video protocol we give a step by step explanation of lentiviral transduction in organoids of primary intestinal epithelium and of processing and downstream analysis of these cultures by quantitative RT-PCR, RNA-microarray and immunohistochemistry.
17:15
Catheterization of Intestinal Loops in Ruminants
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Cited by 4 •
2009
We describe a novel surgical method for catheterizing 'intestinal loops' within the ileum of sheep. Once animals have recovered from surgery and have cleared antibiotics and analgesics, multiple treatments can be deposited directly in loops via the catheters.
09:44
Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Cited by 32 •
2012
Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.
06:55
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Cited by 4 •
2017
Small intestine-dependent bile acid reabsorption and feedback inhibition of hepatic bile acid synthesis is important for systemic homeostasis and health. In this study, we describe a mouse model for ileal resection to evaluate ileectomy-induced bile malabsorption, overaccumulation, and toxicity in mouse intestine.
04:37
Intestinal Crypts Isolation: A Method to Isolate Whole Crypts from Small Intestine of Murine Model
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2023
In this video, we demonstrate a technique to isolate whole crypts from a mouse’s small intestine. The isolated whole crypts can be used to propagate long-lived and self-renewing 3D organoids in vitro.
FAQs
Tissue viability helps determine whether a segment of bowel is suitable for preservation or requires excision. Surgeons also consider the bowel’s blood supply because inadequate perfusion can affect the safety of the remaining tissue and the success of reconstruction. These assessments guide decisions about removing affected areas and restoring intestinal continuity.
An anastomosis reconnects intestinal segments after affected tissue has been removed, restoring continuity through the bowel. A stoma provides an alternative route when reconnection is not appropriate. The choice depends on operative findings, tissue condition, bowel function, and infection risk, making reconstruction a case-specific surgical decision rather than a uniform step.
The access route determines how surgeons reach and modify the intestine during an operation. Intestinal surgery may use an open approach or a minimally invasive approach, while the essential surgical goals remain control of blood supply, management of affected tissue, and restoration or diversion of bowel continuity when necessary.
A typical operative sequence begins with gaining access to the bowel, identifying the diseased or injured segment, and controlling its blood supply. Surgeons then remove or repair tissue as indicated, assess bowel viability and function, and either perform an anastomosis or create a stoma. Infection risk remains an important consideration throughout care.
The procedure may be considered for tumors, inflammatory bowel disease, diverticular disease, intestinal perforation, or obstruction. These conditions can require different operative goals, including removal of affected tissue, repair of injury, or management of disrupted bowel continuity. The underlying diagnosis therefore helps determine the extent and type of surgical modification required.
Postoperative management depends partly on the condition of the bowel and the restoration of normal function. Careful assessment of tissue viability, bowel function, and infection risk supports decisions made during treatment and helps guide recovery. These factors also connect operative findings with broader goals in medicine, including safer healing and gastrointestinal care.