Mucus Plugging Atelectasis

Mucus plugging atelectasis is the collapse or incomplete expansion of lung tissue caused by mucus obstructing an airway, reducing effective ventilation in the affected region. The blockage prevents air from reaching distal alveoli, while trapped gas is gradually absorbed into the blood, decreasing alveolar volume and potentially producing ventilation–perfusion mismatch. This condition can occur with impaired clearance, increased mucus production, airway inflammation, or postoperative shallow breathing, and may present with reduced oxygenation or respiratory distress. Recognizing the mechanism supports clinical evaluation and treatment focused on restoring airway patency, improving secretion clearance, and re-expanding collapsed lung tissue.

Mucus Plugging Atelectasis - Related Videos

Research

JoVE Journal - Immunology and Infection

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

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Cited by 11 •

2017

The mucus plugged airways of cystic fibrosis (CF) patients are an ideal environment for microbial pathogens to thrive. The manuscript describes a novel method for studying the CF lung microbiome in an environment that mimics where they cause disease and how alterations of chemical conditions can drive microbial dynamics.

Education

JoVE Core - Pathophysiology

Atelectasis II: Pathophysiology

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2026

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...

Formation of the Platelet Plug

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2024

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss. As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging

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2025

This study presents a 3D imaging method using whole-mount intestinal tissues and multi-photon microscopy to quantify secreted mucus, enabling precise volumetric analysis and visualization of mucus dynamics in response to stimuli like carbamoylcholine chloride.

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

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Cited by 5 •

2022

The viscoelastic properties of mucus play a critical role in mucociliary clearance. However, traditional mucus rheological techniques require complex and time-consuming approaches. This study provides a detailed protocol for the use of a benchtop rheometer that can rapidly and reliably perform viscoelastic measurements.

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