Total Arch Repair
Total Arch Repair - Related Videos
01:10
The Arch of Aorta
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2024
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively. Encircling the heart, the coronary arteries form a ring-like structure before...
07:04
Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche
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Cited by 5 •
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Here, we present a protocol to culture pharyngeal arches to study the biology of heart and muscle progenitor cells and their microenvironment.
02:25
Overview of DNA Repair
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2020
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage. Chemically...
01:54
Base Excision Repair
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2020
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template. The first step of...
10:10
Reverse Total Shoulder Arthroplasty
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Cited by 5 •
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Reverse total shoulder arthroplasty is indicated for the treatment of conditions that cannot be treated with conventional arthroplasty or other procedures. These primarily include degenerative and incapacitating conditions with irreparable rotator cuff and loss of the normal biomechanical coupling of the shoulder.
FAQs
Because the operation may temporarily interrupt aortic blood flow, perfusion strategies help maintain circulation to the brain and other organs during reconstruction. This is important because the arch supplies blood through major branch arteries; preserving their perfusion supports organ function while surgeons address diseased tissue and establish a new aortic pathway.
The implanted graft serves as the reconstructed aortic pathway after diseased tissue is removed or excluded. The overview identifies synthetic and biologic grafts as possible materials, but it does not assign different indications or performance to either. Graft implantation is paired with reconnecting the major branch arteries so flow can be re-established through the arch.
Removing or excluding diseased tissue targets the segment responsible for the arch’s structural problem rather than simply leaving it within the circulation. The stated goals are to establish a durable aortic pathway and reduce risks associated with complex arch disease, including rupture, malperfusion, and progressive cardiovascular complications.
Reconnecting the major branch arteries is central to restoring the route by which blood reaches the body and brain. It also links the reconstructed arch to the vessels that originally arise from it. This connection is particularly relevant when disease has produced or threatens malperfusion, because the repair aims to re-establish a functional, continuous aortic pathway.
The described workflow has three principal elements: surgeons remove or exclude diseased tissue, place a synthetic or biologic graft, and reconnect the major branch arteries. Because blood flow may be temporarily interrupted, the operation also incorporates strategies intended to maintain cerebral and organ perfusion. Together, these steps reconstruct the arch and restore its circulation.
It may be considered for complex aortic arch aneurysms, dissections, and other structural disease affecting the arch. These conditions differ in their underlying form, but they share the need to address diseased arch tissue and preserve a reliable route for blood flow. The procedure is therefore applied when arch reconstruction is needed to manage the affected aortic segment.
Successful repair is intended to provide a durable aortic pathway while reducing the risk of rupture, malperfusion, and progressive cardiovascular complications. The operation also seeks to maintain blood supply to the brain and body by reconnecting the arch branches. These goals describe the clinical value of the repair without implying a guaranteed result for every patient.
In cardiovascular medicine, the procedure addresses structural disease in a major vessel responsible for distributing blood to the brain and body. Its significance extends beyond replacing tissue: repair must coordinate graft implantation, branch-artery reconnection, and perfusion management. This makes it a reconstructive strategy aimed at both anatomical correction and preservation of circulation during the operation.