Warm Ischemic Time
Warm Ischemic Time - Related Videos
08:47
The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
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Cited by 48 •
2008
The postnatal rat model for hypoxic-ischemic brain injury is a well-established model of human neonatal hypoxic ischemic encephalopathy (HIE). In this article, we describe the model of HIE in post-natal rat pups.
12:00
A Simplified Technique for Producing an Ischemic Wound Model
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Cited by 22 •
2012
We have developed a minimally invasive technique to create a rabbit ischemic ear wound model by dividing the central artery and nerve and the cranial neurovascular bundle. A subcutaneous tunnel then cuts all subcutaneous tissues. This procedure causes minimal skin disruption and can be safely used in diabetic animals.
10:00
Gradient Echo Quantum Memory in Warm Atomic Vapor
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Cited by 2 •
2013
The gradient echo memory is a protocol for storing optical quantum states of light in atomic ensembles. Quantum memory is a key element of a quantum repeater, which can extend the range of quantum key distribution. We outline the operation of the scheme when implemented in a 3-level atomic ensemble.
08:35
Demonstration of the Rat Ischemic Skin Wound Model
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Cited by 32 •
2015
The rat, due to its size, availability, and rather docile behavior, has been utilized as a research model for many years. The goal of this protocol is to utilize the rat as an ischemic skin wound healing model to provide valuable insight into the pathophysiology of chronic wounds.
06:49
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
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Cited by 5 •
2016
The following report describes how to replicate the rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION), using the appropriate dye, contact lens and laser parameters. We also reveal the appropriate steps for evaluating the rNAION lesion in vivo.
FAQs
Warm ischemic time becomes damaging because oxygen deprivation forces cells to rely on anaerobic metabolism, which produces less usable energy and causes metabolic acids to accumulate. As ATP reserves fall, energy-dependent cellular functions deteriorate. Continued exposure can then promote membrane and mitochondrial injury, linking the duration of the interval to declining tissue or organ viability.
Mitochondria are important because they are among the structures injured as oxygen-limited metabolism continues. Their damage occurs alongside ATP depletion and membrane disruption, rather than as an isolated event. This combination helps explain why the interval is clinically meaningful: cellular injury can progress before effective cooling or reperfusion begins.
The interval represents a potentially modifiable part of preservation. Prompt cooling or reperfusion shortens the period in which tissue remains warm and oxygen limited, which can reduce ongoing metabolic stress and help preserve viability. In clinical workflows, timing is therefore not merely recorded retrospectively; it can also guide efforts to improve preservation.
In transplantation and surgery, clinicians use Warm Ischemic Time to characterize procurement conditions and compare graft quality. They also consider it when interpreting biomarkers and estimating risks after implantation. Used consistently, the measure provides a common time-related context for judging how conditions before implantation may relate to subsequent organ outcomes.
The interval provides context when biomarkers are interpreted during graft assessment. Warm ischemic time helps indicate how procurement conditions may have affected the tissue, while biomarker findings provide additional evidence for evaluating graft quality. Together, these measures support more informed estimates of potential risks after implantation without treating elapsed time as the only relevant indicator.
Recording Warm Ischemic Time helps standardize comparisons across transplantation and surgical studies. Researchers can relate differences in procurement conditions and graft quality to later organ outcomes while using a shared time-based measure. This improves consistency when evaluating preservation approaches and supports clearer interpretation of findings about risk after implantation.