Guest Editors
Amir Manbachi
Johns Hopkins University
Dr. Manbachi is an Assistant Professor of Neurosurgery, Biomedical Engineering, Mechanical Engineering, Electrical and Computer Engineering at Johns Hopkins University, and a recipient of the Baltimore Business Journal's 40 under 40 award. He is the engineering PI on a $13.48M award from Department of Defense, and responsible for the assembly of a world-class team of pioneers, including 60 individuals from clinic, academia, and industry. He is the co-founder and director of the HEPIUS Innovation Labs, focusing on the next generation of wearables and implantable medical ultrasound devices for spinal cord injury patients. His research interests include studying applications of ultrasound to various neurosurgical procedures. These applications, spanning both diagnostic cand therapeutic aspects of ultrasound, include imaging the spine and brain, detection of foreign body objects, remote ablation of brain tumors, monitoring of blood flow and tissue perfusion, as well as other upcoming interesting applications such as neuromodulation and drug delivery.
Catherine Gorick
University of Virginia
Dr. Catherine Gorick received her BS in Biological Engineering from the Massachusetts Institute of Technology in 2015. She earned her PhD from the Department of Biomedical Engineering at the University of Virginia in 2021. She conducted her doctoral studies in the laboratory of Dr. Richard Price, specializing in developing focused ultrasound methods to target gene delivery to the cerebral endothelium. She continues her work in Dr. Price’s lab as a postdoctoral fellow. Her current research involves combining focused ultrasound with CRISPR genome editing technology to modulate the expression of efflux transporters in the blood-brain barrier and glioblastoma.
Collection Overview
Focused ultrasound (FUS) has taken off in recent years as a non-invasive tool to facilitate targeted drug and gene delivery as well as precise surgical intervention. FUS can be used to ablate tissue thermally or mechanically in the context of solid tumors or essential tremors or can be combined with intravenous gas-filled microbubbles to deliver therapeutics into specific areas of tissue, most notably across the blood-brain barrier. FUS is often used in conjunction with an imaging modality like ultrasound or MRI to target specific tissue structures with sub-millimeter precision. There are already clinical trials completed or underway for a wide range of pathologies, including neurological diseases, uterine fibroids, and cancers of the brain, liver, breast, bone, or prostate. A tremendous number of additional diseases are also being investigated at the pre-clinical level, through in silico, in vitro, and in vivo approaches. The goal of this collection is to summarize and demonstrate some of these protocols to improve access and awareness of existing focused ultrasound methods and provide baseline knowledge of important techniques to new researchers in the field.
Editorial
Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
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Cited by 5
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2023
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Griffin Mess1,2, Taylor Anderson1,2, Shivani Kapoor3, Rasika Thombre1,2, Ruixing Liang4, Emre Derin1, Kelley M. Kempski-Leadingham1, Santosh K. Yadav5, Betty Tyler1, Amir Manbachi1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine
Articles
Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
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Cited by 10
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2023
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Meghana Bhimreddy1, Denis Routkevitch1,2,3, Andrew M. Hersh1, Ali Mohammadabadi1,3, Arjun K. Menta1, Kelly Jiang1, Carly Weber-Levine1, A. Daniel Davidar1, Joshua Punnoose1,2,3, Kelley M. Kempski Leadingham1,3, Joshua C. Doloff2, Betty Tyler1, Nicholas Theodore1,3, Amir Manbachi1,2,3,4,5,6
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Mechanical Engineering, Johns Hopkins University, 6Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University
Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
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Cited by 1
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2024
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Ruixing Liang1,2, Griffin Mess2,3, Joshua Punnoose2,3, Kelley M. Kempski Leadingham2,3, Constantin Smit2,3, Nitish Thakor1,4, Christa W. Habela3, Betty Tyler3, Yousef Salimpour3, Amir Manbachi1,2,3,4,5,6
1Electrical and Computer Engineering, Johns Hopkins University, 2HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 3Neurosurgery, Johns Hopkins University School of Medicine, 4Biomedical Engineering, Johns Hopkins University School of Medicine, 5Mechanical Engineering, Johns Hopkins University, 6Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine