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Experimental Models for Pediatric Cardiovascular Diseases

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Marta Camprubí Camprubí

Marta Camprubí Camprubí

University of Barcelona, 08950 Barcelona, Spain, Hospital Sant Joan de Déu-Hospital Clinic, BCNatal-Barcelona Center for Maternal Fetal and Neonatal Medicine, Sant Joan de Deu Research Institute, Cardiovascular Research Group

Marta Camprubí Camprubí is a Pediatric specialist in Neonatology that works in SJD Barcelona Children's Hospital, combining basic and clinical research. She has one master’s degree in Neuroscience and one master’s degree in Statistics and methodology. She has focused her research career on studying the mechanism of brain damage in critically ill newborns and its impact on their long-term neurological outcomes. She has conducted several research projects on hypoxic-ischemic brain injury in humans and animal models. Dr. Camprubí leads the neonatal neuro-cardiac critical care unit in the clinical arena. She has conducted several workshops on neuromonitoring within the neonatal intensive care unit.

Joan Sanchez de Toledo

Joan Sanchez de Toledo

Sant Joan de Deu Research Institute, 08950 Barcelona, Spain, Cardiovascular Research Group, Sant Joan de Déu Hospital, Pediatric Cardiology Department; University of Pittsburgh, Pittsburgh, PA 15213, USA, Department of Critical Care Medicine

Dr. Joan Sanchez de Toledo is the chief of the Pediatric Cardiology Department at SJD Barcelona Children's Hospital. Trained in pediatrics, neonatology, pediatric and cardiac critical care medicine, he works in the cardiac intensive care unit at Children´s Hospital of Pittsburgh, and more recently, he became the chief of the Pediatric Cardiology Department at SJD Barcelona Children’s Hospital. Moreover, Dr. Sanchez de Toledo is an Assistant professor in the Department of Critical Care Medicine at the University of Pittsburgh. Since his beginnings, one of his main focuses of interest was the long-term outcomes of children with cardiac diseases and more precisely, the neurodevelopmental outcome of children suffering from acute illnesses. Considering his experience in basic research, while in Pittsburgh, he collaborates with the Safar Center for Resuscitation Research where he worked on the rat model of cardiopulmonary bypass. Upon moving to Barcelona, he develops the first experimental pediatric small animal cardiopulmonary bypass model existing in Spain.

Collection Overview

Congenital heart disease (CHD) is the most prevalent congenital malformation, affecting approximately a million births worldwide annually. In the last decades, advances in surgical techniques and perioperative management of CHD have reduced mortality rates. Nowadays, nine out of ten infants with CHD reach adulthood. Nevertheless, with the improvement in survival, new long-term outcome disabilities have flourished, decreasing the quality of life among survivors.

Animal models could be a great tool to evaluate the safety and efficacy of new treatment strategies, devices, and surgical technics. Moreover, they will be of paramount importance to the elucidated underlying mechanism of injury associated with heart surgery.

The aim of this collection is to provide researchers with some new tools to help for a better understanding of physiology and mechanisms of injury associated with pediatric cardiovascular disease.  

Articles

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
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Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

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Cited by 1

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2023

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Abstracts

A prepubertal mouse model of right ventricular volume overload

Lincai Ye*1

1Shanghai Children’s Medical Center