Current Methods In Immunometabolism Research

TOPICAL COLLECTIONS

Guest Editors

Heriberto Prado-Garcia

National Institute of Respiratory Diseases, Onco-Immunobiology Laboratory, Department of Chronic-Degenerative Diseases

Dr. Heriberto Prado-Garcia is a Medical Scientist at the National Institute of Respiratory Diseases (Mexico City). He is the chief of the Onco-Immunobiology Lab. His research focuses on CD8+ T cells and tumor evasion mechanisms that affect this immune population. His research involves analyzing the metabolic profile of CD8+ T cells in order to determine potential changes generated by the tumor microenvironment. Another active area of research is the study of tumor cell metabolism and how metabolic changes facilitate immune evasion mechanisms. He works with multiple groups to characterize novel tactics for developing cancer chemotherapies. Dr. Prado-Garcia is the current Coordinator of the Cytometry Chapter of the Mexican Society of Immunology.

Mariana Segovia-Mendoza

National Autonomous University of Mexico, Department of Pharmacology, Faculty of Medicine

Dr. Segovia is currently working as an Associate Professor at the Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico. She completed her PhD at the National Institute of Nutrition in Mexico City. Her research was focused on breast cancer, hormones, and targeted therapy. She did a research stay in the Department of Biochemistry and Molecular Biology at Drexel University College of Medicine in Philadelphia, United States. Dr. Segovia served as a postdoctoral researcher in the Institute of Biomedical Research's Department of Neuroimmunoendocrinology, where she studied the tumor microenvironment and endocrine disruptor compounds in breast cancer patients. Dr. Segovia has served as a Guest Associate Editor in several journals, including Frontiers in Oncology and Frontiers in Toxicology.

Collection Overview

Immunometabolism research can help us understand how immune cells react in different situations (e.g., infection, cancer, and autoimmunity). Although the study of cellular metabolism is not new, it has grown significantly since the uncovering of the Warburg effect and the study of metabolic reprogramming in tumor cells. Immunologists have proven that the simultaneous metabolic reprogramming of cancer and immune cells is a possible determinant of the antitumor immune response in cancer. Furthermore, cellular metabolism does more than just produce energy and biomass; there is a subtle interaction in metabolic pathways that affect basic immunological processes and govern how immune cells respond. Recent technological breakthroughs have provided researchers with the resources required to obtain a greater understanding of the alterations in immune cell metabolism; nevertheless, accessible methodologies are required to support this field of research as well as to generate reproducible results. Thus, this Methods Collection aims to provide cutting-edge protocols for studying immune cell metabolism in many different contexts, including but not limited to in vitro and in vivo experiments, cytomics, and metabolomics approaches.