Guest Editors
Tianhe Huang
Zhongnan Hospital of Wuhan University, Department of Radiation and Medical Oncology
Dr. Tianhe Huan is an oncologist at the Zhongnan Hospital of Wuhan University,. His team focuses on the clinical treatment for patients with gastric cancer and colorectal cancer, and they have several ongoing clinical trials to prove the potential treatment strategies for patients with therapy resistance. His research interests are based on his experience in the Xin Lab at the University of Notre Dame. From 2018 to 2021, he successfully constructed a genetically engineered mouse model for penile squamous cell carcinoma and prostate cancer. With these models, he investigated the pre-clinical treatment strategies for penile squamous cell carcinoma and detected the mechanism of premetastatic niche change during distant metastasis of prostate cancer. Now he is also trying to generate digestive system tumor mouse models to better serve our clinical works.
Jieye Lin
University of California, David Geffen School of Medicine
Dr. Jieye Lin is currently working as a postdoctoral scholar in Dr. Tamir Gonen’s lab at the David Geffen School of Medicine, University of California, Los Angeles. His lab focuses on the method development of microcrystal electron diffraction (MicroED) as well as its application in the structural analysis of novel pharmaceutical compounds, membrane proteins, etc. His current research interests are (1) automation of MicroED data collection and process; (2) determination and structure analysis of novel pharmaceutical compounds. The former aims to automate the MicroED pipeline to minimize human involvement and provide unbiased and reproducible diffraction data, the latter is an application of MicroED in the study of pharmaceutical compounds which cannot form large and well-ordered crystals for conventional X-ray diffraction.
Collection Overview
Mouse tumor models are essential to cancer research, especially for the mechanisms of probing and pre-clinical treatment evaluations. When creating a mouse model, it is critical that it corresponds to our research objectives. We should decide which mouse tumor models are needed: genetically engineered mouse or xenograft mouse models, orthotopic or metastatic models. Given that different tumor cells have different biological characteristics and an aggressive one may easily form a xenograft or distant metastasis, we may also need to consider which tumor cells are the best for our research. Sometimes we also need to know the schedules for cancer formation. If we share the information about the generated mouse models, it may help other researchers to save time and money.
This Methods Collection describes a set of critically important and complementary techniques that may be used to achieve these goals. The collection focuses on not only the common cancers but also the rare and neglected cancer types
Articles
Abstracts
A Rat Model of Pouchitis After Proctocolectomy and Ileal Pouch-Anal Anastomosis Using DSS
Gang Liu*1
1Tianjin Medical University General Hospital, Tianjin, China