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TOPICAL COLLECTIONS

Multi-scale Fabrication Techniques for Developing Scaffolds and Devices for Tissue Engineering and Regenerative Medicine
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Prasoon Kumar

Prasoon Kumar

National Institute of Technology Rourkela

Prasoon did his Bachelor of Engineering (BE) from Birla Institute of Technology, MESRA, Ranchi, in the Department of Biotechnology from 2004-2008. Thereafter, he pursued a Master of Technology from the Indian Institute of Technology, Kanpur, in the area of Bioengineering with a specialization in tissue engineering and biomechanics from 2008-2010. Then, he worked at the Computational Instrumentation division of the Central Scientific Instruments Organization (A CSIR lab), Chandigarh, from 2010-2011 in an area of biomedical signal and image processing in collaboration with the Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi. Thereafter, he pursued a joint PhD program at IITB-Monash Research Academy (Indian Institute of Technology, Bombay and Monash University, Clayton, Melbourne, Australia) in the Department of Mechanical Engineering, specializing in design engineering from 2011-2018. He worked at the Indian Institute of Science, Bangalore, to pursue his post-doctoral training in the Department of Materials Engineering in the area of Organ-on-chip devices from 2017-2019. Later, he worked as an Assistant Professor in the Department of Medical Devices at the National Institute of Pharmaceutical Education and Research-Ahmadabad from 2019-2020. In June 2020, he joined as an Assistant Professor in the Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela. He has published over 25 articles in peer-reviewed journals and filed for over 5 patents. His research area includes micromanufacturing, additive manufacturing, biomaterials, diagnostic devices and advanced materials. His lab focuses on developing innovative devices by employing design principles, materials understanding and manufacturing processes to address healthcare challenges. 

Sachin Kumar

Sachin Kumar

Indian Institute of Technology Delhi

Sachin Kumar B received his doctoral degree (PhD) in Biomaterials from the Indian Institute of Science (IISc), Bangalore, India. After completing his PhD, he received a prestigious Humboldt postdoctoral fellowship at Max-Planck Institute for Polymer Research (MPIP, Germany) to research how protein structure at the molecular level influences stem cell response. Upon completing the Humboldt postdoctoral fellowship, he moved to The University of Texas (UT) in Austin, USA, to continue researching the molecular understanding of fibrin-platelet interaction during Hemostasis. In 2021, Sachin joined the Indian Institute of Technology Delhi (IIT-D) as an Assistant Professor at the Centre for Biomedical Engineering. His research lab focuses on interdisciplinary field biomaterials, bio-interface, biofabrication, and tissue engineering to understand how the physicochemical properties of the materials regulate cellular functions, tissue regeneration, and disease progression. Such fundamental understanding helps to design and fabricate functional biomaterials to regenerate tissue and treat pathological diseases at the clinical level. 

Kaushik Choudhury

Kaushik Choudhury

Centre for Cellular and Molecular Platforms (C-CAMP), Iota Design & Innovations Lab Pvt. Ltd. (IDIL)

Kaushik Choudhury earned his PhD in laser interferometric observations related to the ablation of metals jointly from the Indian Institute of Technology Bombay (India) and Monash University (Australia) in 2018. He holds a master’s degree in physics from the Indian Institute of Technology Roorkee. His research interests are 3D printing and instrumentation for biomedical applications. He is keen on developing products in the healthcare domain that are affordable and can reach the masses. With this vision, he has co-founded a start-up, Iota Design & Innovations Lab Pvt. Ltd. (Gandhinagar, India), to design, develop and commercialize affordable and innovative healthcare solutions. He is presently a board member and one of the company's directors. He holds the position of Translation Scientist in the Discovery to Innovation Accelerator (DIA) of the Center for Cellular and Molecular Platforms (Bengaluru, India). He is a team member that translates the ideas developed in academic institutions across India into novel products for industries to take them forward and commercialize. 

Collection Overview

Multi-scale fabrication techniques play a vital role in designing and developing scaffolds and devices for tissue engineering applications. The holy grail for any tissue engineer is to design and develop scaffolds/devices that offer biomimicking topological features in the chemical and mechanical microenvironment. Towards this, processing materials (polymers, composites, biopolymers) through multi-scale fabrication techniques can enable forming such biomimicking scaffolds/devices. Although several methods, such as electrospinning, freeze drying, soft-lithography, 3D printing, bio-printing, and 4D printing, are available, they have their pros and cons. Some of these techniques are widely used and routinely modified to suit a particular need.

 

This Methods Collection showcases various fabrication techniques, including 3D printing methods like fused deposition molding, ink-jet binding, and selective laser sintering. Additionally, lithography techniques like stereolithography, micro-stereolithography, and 2-photon polymerization, among others, are featured alongside bio-printing, 4D printing, electrospinning, and its variants, as well as phase separations, particulate leaching, freeze drying, and gas forming. The collection may also include microfabrication and biofabrication technologies that enable the production of 3D, multi-scale structures.

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2024

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