Neurological disorders encompass diseases affecting both the peripheral and central nervous systems, and they profoundly impact millions of individuals worldwide. For instance, strokes alone result in over 6 million deaths annually, while the global prevalence of epilepsy exceeds 50 million people. Dementia affects approximately 47.5 million individuals worldwide, with 7.7 million new cases reported annually. Alzheimer's disease, accounting for 60-70% of dementia cases, is the leading cause. While considerable progress has been made in recent decades, effective treatments remain elusive. Therefore, publishing methodological reports is paramount to advancing research in this field.
Through this Methods Collection, we cordially invite researchers from around the world to contribute their current tools and methods that encompass various aspects of neurological disorders. The approaches may include but are not limited to, innovative in vivo (mammalian and non-mammalian) and in vitro experimental approaches, microscopy techniques, computational methods, behavioral tests, electrophysiological recordings, and more.
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2025
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1Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, 2Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, 3NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University
An Optimized DCE-MRI Protocol for Glymphatic Imaging in Awake and Mechanically Ventilated Anesthetized Mice
Juchen Li*1,
Tianming Zha1,
Binshi Bo2,
Mengchao Pei2,
Sheng Zhang1,
Xinyue Lan1,
Zhifeng Liang2,
Fang Fang*1
1Department of Pain Medicine, Zhongshan Hospital, Fudan University, Shanghai, China,
2Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China