
Daniel Neill
Division of Molecular Microbiology, University of Dundee
Dr. Neill’s lab studies bacterial infections of the human airways. In particular, the lab seeks to understand how the physical, chemical and biological environment of the respiratory tract influences bacterial phenotypes, including those associated with virulence and antimicrobial resistance. The lab focuses on the relationship between upper airway commensalism and lung pathogenesis and aim to define the host and pathogen factors that drive a switch between these two modes of life. Dr. Neill, with his lab strives to improve on existing in vitro and in vivo models of infection, to better capture the key conditions of the respiratory tract in health and disease. A long-term goal is the development of novel therapeutics and vaccines for treatment and prevention of bacterial respiratory diseases.

Miguel Cámara
School of Life Sciences and Biodiscovery Institute, University of Nottingham
Prof. Miguel Cámara is Co-Director of the National Biofilms Innovation Centre (NBIC) working with academic and industrial partners on different areas of biofilm research and innovation. He has many years of expertise in quorum sensing-mediated bacterial cell-cell signalling mechanisms with a particular emphasis on the Cystic Fibrosis opportunistic pathogen Pseudomonas aeruginosa. He has led several drug discovery programs aiming at reducing the impact of antimicrobial resistance through novel anti-virulence target discovery and the design of inhibitors against these, mainly targeting quorum sensing-driven mechanisms. Some research areas he currently studies on include: (i) identification of novel biomarkers of infection for the development of point of care diagnostics; (ii) molecular mechanisms of biofilm development and adaptation to low oxygen conditions; (iv) identification of novel drugs which prevent biofilm formation or sensitise them to antibiotics; (v) mechanisms of interactions between biofilms and the human host.

Joanne Fothergill
Department of Clinical Infection, Microbiology and Immunology, University of Liverpool
Dr. Fothergill's research activities are focused on understanding the mechanisms of pathogens, particularly Pseudomonas aeruginosa, in disease. Her work delves into chronic infections. Employing genomics, molecular microbiology, and population studies, she investigates P. aeruginosa's interactions in polymicrobial biofilms, for insights into pathogen evolution. With an expertise in bacterial genomics, molecular epidemiology, and antimicrobial resistance, Dr. Fothergill has developed diagnostic tests for P. aeruginosa. Additionally, she also explores infections caused by Escherichia coli. As deputy director of the Microbiome Innovation Centre at the University of Liverpool, she studies microbiome changes during disease treatment and its impact on pathogen biology.
Infection is a major cause of global morbidity and mortality. The study of microbial physiology, host-pathogen interactions, and antimicrobial drug development is hampered by the difficulty of capturing the complexity of infection-relevant environments under laboratory conditions. Substantial research has been devoted to developing new model systems and improving upon existing ones, but choosing a model appropriate for a given research question remains a challenge.
This Methods Collection aims to highlight recent advances in the development and validation of infection-relevant models. We aim to encompass a wide variety of models, ranging from high-throughput, chemically-defined bacterial culture media that reflect host environments to models of host-pathogen interactions and advanced systems for studying drug pharmacokinetics under infection-relevant conditions.
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Cited by 3
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2024
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1School of Life Sciences, Biodiscovery Institute, University of Nottingham, 2MiDx Ltd, Biodiscovery Institute, University of Nottingham, 3School of Life Sciences, Queen's Medical Centre, University of Nottingham, 4National Biofilms Innovation Centre, School of Life Sciences, Biodiscovery Institute, University of Nottingham
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Cited by 8
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2024
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2025
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Muhanna Alshehri1,2, Saeed Alqahtani1,2,3, Pranitha Murali2,4,5, Christopher Delaney1,2, William Johnston2,4,5, Jason L. Brown1,2
1Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, 2Glasgow Biofilm Research Network, 3Department of Restorative Dental Sciences, College of Dentistry, Jouf University, 4Department of Biological and Biomedical Sciences, Glasgow Caledonian University, 5Safeguarding Health through Infection Prevention Research Group, Glasgow Caledonian University
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2025
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Lilian K. Fischer Sigel1,2, Daiana S. Sánchez1,2, Alejandro Balestracci3, Cristina Ibarra2,4, Claudia Silberstein1,2
1Laboratorio de Fisiología Renal, Departamento de Ciencias Fisiológicas, Facultad de Ciencias Médicas, Universidad de Buenos Aires (UBA), 2Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay), Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), 3Servicio de Nefrología, Hospital General de Niños Pedro de Elizalde, 4Laboratorio de Fisiopatogenia, Departamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad de Buenos Aires
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2026
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Sarah Aimee Boardman1,2, Jenna Marie Rosano3, Claire Dawn Hetherington1,2, Cordelia Dunai1,2,4, Thomas David Bateman-Price5, Marie Held6, Thomas Waring6, Marco Marcello6, Franklyn Nkongho Egbe1,2, Mark Alexander Ellul1,2,4,7, Stephen T.J. Ray2,8,9, Riccardo Vincenzo D'Elia5,10, Adjanie Patabendige1,2,11,12, Esther García-Tuñón*13,14, Gwen Fewell*3, Benedict Daniel Michael*1,2,4,7
1Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Science, University of Liverpool, 2Liverpool Interdisciplinary Neuroscience Centre, University of Liverpool, 3SynVivo Inc., 4NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, University of Liverpool, 5Human and Biological Advantage, Defence Science and Technology Laboratory (Dstl), 6Centre for Cell Imaging, Liverpool Shared Research Facilities, University of Liverpool, 7Department of Neurology, Walton Centre Foundation Trust, 8Department of Paediatric Infectious Disease and Immunology, Oxford University Hospitals NHS Foundation Trust, 9Oxford Vaccine Group, Department of Paediatrics, University of Oxford, 10Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS), University of Strathclyde, 11Metabolic Disorders and Cancer Research Centre, College of Science and Engineering, University of Derby, 12Liverpool Centre for Cardiovascular Science, University of Liverpool, 13School of Engineering, University of Liverpool, 14Materials Innovation Factory, University of Liverpool
Cystic Fibrosis-Specific Hollow Fiber Infection Model (HFIM) for Optimizing Antibiotic Therapy for People with CF
Ashwani Kumar 1,
Nicola Farrington1,
Shampa Das*1,
Joanne L Fothergill2
1Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom,
2Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK
Development of a cystic fibrosis aggregate polymicrobial biofilm model to observe changes in virulence gene expression
Tegan Hibbert1,
Hollie Leighton1,
Grace Ritchie1,
Daniel Neill2,
Joanne Fothergill*1
1University of Liverpool,
2University of Dundee
Considerations for use of Galleria mellonella as an antimicrobial screening model
Thomas Barton*1
1University of Dundee
Exploring Tenebrio molitor as a Model for Discovering New Antifungal Agents Against Candidozyma auris
Susana Johann*1,
Aline Dias Valerio1,
Anna Paula Tironi1,
Renata Oliveira1
1Universidade Federal de Minas Gerais