Guest Editor
Collection Overview
Covering ~40% of the human body, skeletal muscle is a major organ, supporting critical functions ranging from movement and respiration, to metabolism and temperature regulation. Importantly, it has a unique capacity to self-repair after injury, with this regenerative capacity ensuring complete functional and structural recovery from serious damage in less than a month. Several cells have been implicated in this remarkable repair capacity, with the satellite cells (the muscle stem cells) having a central role and being the focus of multiple methods of fundamental or translational research.
To study the molecular and cellular events underlying skeletal muscle health and pathology, several assays have been developed to analyze skeletal muscle on the functional, molecular, and cellular levels. Each technique has its own strengths, with in vivo testing on animal models representing the option with the most relevance to humans and the complexity of living organisms. Its counterpart, in vitro testing, is gaining ground as research groups worldwide are striving to minimize animal research in view of the internationally recognized 3R rules. This Methods Collection aims to provide an overview of the essential toolkit to study muscle in a variety of in vivo and in vitro systems.
Editorial
Articles
In Vivo Measurement of Hindlimb Dorsiflexor Isometric Torque from Pig
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Cited by 6
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2021
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In vivo Measurement of Knee Extensor Muscle Function in Mice
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Cited by 14
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2021
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Camille R. Brightwell1,2, Ted G. Graber3, Benjamin D. Brightwell4,5, Matthew Borkowski6, Brian Noehren5,7, Christopher S. Fry1,2
1Department of Athletic Training and Clinical Nutrition, University of Kentucky, 2Center for Muscle Biology, University of Kentucky, 3Department of Physical Therapy, East Carolina University, 4Kinesiology and Health Promotion Graduate Program, University of Kentucky, 5Biomotion Lab, College of Health Sciences, University of Kentucky, 6Aurora Scientific, 7Department of Physical Therapy, College of Health Sciences, University of Kentucky
Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry
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Cited by 3
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2024
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1John T. Milliken Department of Medicine, Division of Nutritional Sciences and Obesity Medicine, Washington University School of Medicine, 2Nutrition and Obesity Research Center, Cellular and Molecular Biology Core, Washington University School of Medicine, 3Nutrition and Obesity Research Center, Animal Model Research Core, Washington University School of Medicine
Abstracts
Impact of Boric Acid on Mesenchymal Stem Cell Therapy, Lactate Dehydrogenase, and Muscle Performance in Sports
Sevil Kestane*1,
Ozlem KARA*2
1Kirsehir Ahi Evran University, Medicine Faculty, Physiology Department,
2Kirsehir Ahi Evran University, Medicine Faculty, Histology and Embryology Department