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Collection Overview
Bone has the unique ability of scarless healing. Successful bone healing and regeneration requires the tight interaction of different cell types, activation of many signaling pathways, and coordinated release of cytokines and mediators. The molecular details of the bone healing process are still not well understood. In the past decades, bone healing was mainly studied in large animals like dogs, rabbits, or sheep. In recent years, mice and rats have become increasingly popular as a model organism for fracture healing research and even zebrafish can be used to study bone regeneration. Various bone defect healing, bone regeneration, and fracture healing models have been developed for large and small animal models to allow standardized investigations. Models might not only differ in the used species, but also in the chosen bone location (long bones vs. non-loaded bones; diaphyseal bone vs. metaphyseal bone) and the used fracture type and implant. Different models are required to answer different research questions, e.g. focusing on the biomechanical environment, molecular mechanisms of healing, or translational relevance. This methods collection will provide an overview of cutting edge basic and translational approaches to study the complex process of bone healing.
Articles
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
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2022
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Aayush Aryal1, Pawan Kumar Pagaku2, Devanjan Dey2, Sagar Tyagi2, Vadanya Shrivastava2, Aditi Bhattacharya2, Sweety Rani2, Debdatta Nayak6, Anil Khurana6, Puneet Khanna3, Ankur Goyal4, Asit Ranjan Mridha5, Bhavuk Garg1, Sudip Sen2
1Department of Orthopedics, All India Institute of Medical Sciences (AIIMS), 2Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 3Department of Anaesthesiology Pain Medicine and Critical Care, All India Institute of Medical Sciences (AIIMS), 4Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), 5Department of Pathology, All India Institute of Medical Sciences (AIIMS), 6Central Council for Research in Homoeopathy (CCRH)
Abstracts
Comprehensive analysis of concomitant long bone fracture with traumatic brain injury
Charles Lam1,
Adam Ferguson2,
Ralph Marcucio3,
Kazuhito Morioka4,
Abel Torres-Espín5,
Theodore Miclau III*6,
Jacqueline Bresnahan5
11 Orthopaedic Trauma Institute (OTI), Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), CA, United States,
22 Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), CA, United States; 3 San Francisco Veterans Affairs Healthcare System (SFVAHCS), San Francisco, CA, USA,
31 Orthopaedic Trauma Institute (OTI), Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), , CA, United States,
41 Orthopaedic Trauma Institute (OTI), Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG); 2 Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), CA, United States,
52 Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), CA, United States,
61 Orthopaedic Trauma Institute (OTI), Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), CA, USA