Adolescent Female Mice
Adolescent Female Mice - Related Videos
07:15
Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
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Cited by 3 •
2024
We developed an accelerated social defeat stress model for adolescent C57BL/6 mice, which works in both males and females and allows exposure during discrete adolescent periods. Exposure to this model induces social avoidance, but only in a subset of defeated male and female mice.
02:54
Establishment of a Urinary Tract Infection Model in Female Mice
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2025
This video demonstrates the establishment of uropathogenic Escherichia coli infection in a female mouse bladder through transurethral catheter instillation. The injected bacteria successfully establish a urinary tract infection within the bladder, providing a valuable platform for studying healthcare-associated diseases related to the urinary tract.
07:06
Chronic Social Defeat Stress in Early Adolescent Male Mice
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Cited by 3 •
2025
This protocol details how to perform 10 day chronic social defeat stress in early adolescent male mice to produce long-lasting social avoidance in adulthood in more than 60% of mice.
06:15
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
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Cited by 17 •
2017
Here, we present a protocol that provoked cortisol reactivity in a vulnerable adolescent Mexican American sample utilizing a modified version of the Trier Social Stress Test (TSST). Saliva samples were collected at baseline, 15, 30, and 45 min post-TSST onset. Future research could utilize this modified TSST with vulnerable youth.
07:51
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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2025
Δ9-tetrahydrocannabinol (THC) is the intoxicating constituent in cannabis and a controlled substance in the United States. This article outlines standard procedures for obtaining, storing, and administering THC to mice complying with current legal regulations and briefly introduces a method to assess basic pharmacodynamic effects of THC in rodents.
FAQs
Changing ovarian hormone activity interacts with neural circuits that support learning, social interaction, stress responses, and motivation. Because these hormonal changes occur during rapid brain development, the same behavioral process may appear differently across maturation. Studying this interaction helps researchers connect developmental physiology with age- and sex-dependent behavioral patterns rather than treating behavior as biologically static.
Developmental stage provides essential context for interpreting behavioral results because adolescent female mice undergo simultaneous brain, hormonal, and behavioral change. An observed difference may reflect maturation rather than an experimental manipulation alone. Comparing behavior across stages can therefore reveal how age influences learning, social behavior, stress responses, or motivation and can separate developmental effects from broader treatment effects.
Behavioral outcomes can reflect interactions among maturation, ovarian hormone activity, environmental influences, and experimental conditions. These factors may affect neural systems related to learning, social interaction, stress, and motivation, producing patterns that depend on both age and sex. Considering these variables helps researchers interpret variation more accurately and identify mechanisms associated with development or disease risk.
Behavioral assays can evaluate processes linked to learning, social interaction, stress responses, and motivation. The resulting patterns provide measurable outcomes for examining how behavior changes during maturation or responds to environmental influences. They also allow researchers to study whether pharmacological or genetic manipulations alter specific behavioral domains, supporting more focused interpretations than a single general behavior measure.
Researchers use pharmacological or genetic manipulations to test how particular biological changes affect behavior during adolescence. Behavioral assays then provide outcomes that can be compared with untreated or otherwise different experimental conditions, when included in a study. This approach helps connect altered biological function with learning, social interaction, stress-related behavior, or motivation while preserving developmental context.
These mice offer a model for examining how biological sex and developmental stage shape behavior during a period of rapid change. Findings can clarify mechanisms associated with environmental influences and psychiatric disease risk, while also showing how responses to experimental manipulations vary with maturation. Such results may contribute to understanding behavioral and biological processes relevant to human adolescent health.