Automated Sample Processing

Automated sample processing is the use of programmable instruments and robotic systems to prepare, handle, and analyze biological or chemical samples with limited manual intervention. These workflows combine liquid handling, timed transfers, mixing, centrifugation, temperature control, and barcode-based tracking to perform repeatable steps under standardized conditions. In bioengineering, automation supports high-throughput assays, cell and tissue analysis, molecular biology, and biomanufacturing by improving consistency, reducing handling errors, and increasing experimental capacity. Integrated platforms can also connect sample preparation with analytical instruments and data systems, enabling more reproducible experiments, efficient resource use, and scalable research or production workflows.

Automated Sample Processing - Related Videos

Research

JoVE Journal - Biology

Digital Microfluidics for Automated Proteomic Processing

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Cited by 30 •

2009

Digital Microfluidics is a technique characterized by the manipulation of discrete droplets (~nL - mL) on an array of electrodes by the application of electrical fields. It is well-suited for carrying out rapid, sequential, miniaturized automated biochemical assays. Here, we report a platform capable of automating several proteomic processing steps.

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

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Cited by 8 •

2021

Detailed protocol and three Python scripts are provided for operating an open-source robotic liquid handling system to perform semi-automated protein sample preparation for mass spectrometry experiments, covering detergent removal, protein digestion, and peptide desalting steps.

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach

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2016

This protocol describes a method to quantify mouse sociability. Mice are videotaped as they move and interact in a special cage. Movie processing allows for the automated quantification of sociability with excellent accuracy and reliability.

A Simple Method for Automated Solid Phase Extraction of Water Samples for Immunological Analysis of Small Pollutants

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Cited by 2 •

2016

A protocol for the extraction and pre-concentration of estradiol from water samples by using an automated and miniaturized system is presented.

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

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Cited by 7 •

2019

Automation is key to upscaling and cost management in cell manufacturing. This manuscript describes the use of a counterflow centrifugal cell processing device for automating the buffer exchange and cell concentration steps for small-scale bioprocessing.

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