Benchtop Fabrication
Benchtop Fabrication - Related Videos
12:54
Operation of a Benchtop Bioreactor
0 Views •
Cited by 9 •
2013
Fermentors are used to increase culture yield and productivity of bioengineered cells. After screening multiple microbial or animal cell culture candidates in shake flasks, the next logical step is to increase the selected culture’s biomass with the fermentor. This video demonstrates the setup and operation of a typical benchtop bioreactor system.
08:47
Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
0 Views •
Cited by 5 •
2022
The viscoelastic properties of mucus play a critical role in mucociliary clearance. However, traditional mucus rheological techniques require complex and time-consuming approaches. This study provides a detailed protocol for the use of a benchtop rheometer that can rapidly and reliably perform viscoelastic measurements.
07:36
Fabricating Nanogaps by Nanoskiving
0 Views •
Cited by 3 •
2013
The fabrication of electrically addressable, high-aspect-ratio (> 1000:1) metal nanowires separated by gaps of single nanometers using either sacrificial layers of aluminum and silver or self-assembled monolayers as templates is described. These nanogap structures are fabricated without a clean room or any photo- or electron-beam lithographic processes by a form of edge lithography known as nanoskiving.
08:29
Fabrication of Amperometric Electrodes
0 Views •
Cited by 8 •
2009
This protocol describes how to generate carbon fiber electrodes. The electrodes are subsequently used to detect catecholamine release from vesicles with carbon fiber amperometry.
05:40
Fabricating Cotton Analytical Devices
0 Views •
2016
To investigate simple fabrication approaches for multiple assay needs, we created a fluid-absorbing channel system made of cotton material. This device was used to establish a multiple detection platform, and solve contamination issues that commonly affect lateral flow-based biomedical devices, for clinical urinalysis of nitrite, total protein, and urobilinogen.
FAQs
Computer-aided design provides the starting specification for producing a physical prototype through machining, molding, laser cutting, additive manufacturing, or manual assembly. The resulting component can then undergo dimensional and functional testing, allowing researchers to compare the physical result with the intended design. This translation connects digital planning with practical evaluation before further development or scale-up.
Dimensional testing determines whether a fabricated component matches the intended physical design, while functional testing examines whether it performs its experimental purpose. Considering both results helps researchers distinguish shape-related problems from performance-related problems. Together, these evaluations guide design modifications, support rapid iteration, and provide evidence about whether a prototype is ready for continued development.
Benchtop fabrication emphasizes accessible laboratory tools, small-scale construction, and modification rather than industrial manufacturing systems. This setting lets laboratories change designs as experimental requirements develop and evaluate prototypes before committing to scale-up. The approach can therefore reduce development time and cost while supporting customized devices or components for specific biological experiments.
A typical workflow begins with a computer-aided design, followed by physical construction using an appropriate laboratory fabrication process or manual assembly. Researchers then perform dimensional and functional testing on the prototype. Test results inform modifications to the design or fabrication process, and the cycle can be repeated until the component meets the needs of the planned biological experiment.
The approach supports development of microfluidic platforms, tissue-engineering scaffolds, biosensors, and research instruments. These systems often require designs tailored to particular biological experiments, making small-scale construction and modification useful during development. Prototypes can be evaluated physically before scale-up, helping researchers assess whether a design is suitable for its intended experimental role.
Laboratories can modify a prototype when experimental requirements change instead of relying on a fixed, industrially produced design. Accessible tools support construction or alteration of components for specific biological studies, followed by renewed dimensional and functional testing. This flexibility allows researchers to adapt microfluidic devices, scaffolds, biosensors, or instruments while maintaining an iterative development process.