Custom Cranial Implants

Custom cranial implants are patient-specific medical devices designed to replace portions of the skull lost or damaged by trauma, surgery, or disease. In bioengineering, clinicians use medical imaging to create a three-dimensional model of the defect, then manufacture an implant whose geometry matches the patient’s anatomy and secure it to surrounding bone or cranial structures. Materials such as titanium, polymers, or ceramic-based compounds can provide structural protection, dimensional stability, and tissue compatibility. These implants restore cranial contour and mechanical shielding while supporting surgical reconstruction, improving fit compared with standard components, and advancing personalized treatment through computer-aided design and additive manufacturing.

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Research

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Implantation of Cranial Imaging Window in Mouse Model: A Surgical Procedure to Implant Glass-based Coverslip for Stable Optical Access to Regions of Murine Brain

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2023

This video presents a surgical procedure to implant cranial window in a mouse model for stable optical access to different regions of the brain.

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice

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Cited by 7 •

2021

Presented here is a protocol for the implantation of a chronic cranial window for the longitudinal imaging of brain cells in awake, head-restrained mice.

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window

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Cited by 36 •

2010

Intravital microscopy to follow temporal and spatial hemodynamic and inflammatory events in the pial microcirculation.

Cranial Ring Assembly Installation in Mouse Model: A Surgical Procedure to Implant Visualization Window Assembly on Murine Skull for High-resolution Skull Bone Marrow Imaging

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2025

In this video, we describe a surgical procedure to implant a cranial ring assembly on the exposed skull bone and further immobilize the mouse’s head for high-resolution brain imaging for a long duration.

Chronic Cranial Window Technique for Repeated Cortical Recordings During Anesthesia in Pigs

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2025

This study presents a scalable, reliable, and reproducible method for repeated chronic cortical recordings in a porcine model. The method has applications in various fields of neuroscience, including pain research and neurological disease diagnostics.

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