Fiber Extrusion
Fiber Extrusion - Related Videos
10:22
Demonstration of the Power Law Model Through Extrusion
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2023
Source: Kerry M. Dooley and Michael G. Benton, Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA Polymer melts are often formed into simple shapes or "extrudates", such as cylindrical pellets, flat sheets, or pipe, using an extruder.1 Polyolefins are among the most common extrudable polymers. Extrusion involves transporting and melting solid feed, which is sometimes mixed with non-polymeric materials, and the pressure build-up and transport of the melt or mixture.
09:39
Live Imaging of Cell Extrusion from the Epidermis of Developing Zebrafish
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Cited by 20 •
2011
Dying cells are extruded from epithelial tissues by concerted contraction of neighboring cells without disrupting barrier function. The optical clarity of developing zebrafish provides an excellent system to visualize extrusion in living epithelia. Here we describe methods to induce and image extrusion in the larval zebrafish epidermis at cellular resolution.
08:10
Hydraulic Extrusion of the Spinal Cord and Isolation of Dorsal Root Ganglia in Rodents
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Cited by 110 •
2017
Here, we present a protocol for hydraulic extrusion of the spinal cord as well as identification and isolation of specific dorsal root ganglia (DRGs) in the same rodent. Compared to standard spinal cord isolation methods, this method is significantly faster and reduces the risk of tissue damage.
08:28
Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers
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Cited by 6 •
2017
A protocol for the microfluidic spinning and microstructure characterization of regenerated silk fibroin monofilament is presented.
11:35
Constant Pressure-controlled Extrusion Method for the Preparation of Nano-sized Lipid Vesicles
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Cited by 29 •
2012
This protocol describes an extrusion method for preparing lipid vesicles of sub-micron sizes with a high degree of homogeneity. This method uses a pressure-controlled system with controlled nitrogen flow rates for liposome preparation. The lipid preparation1,2, liposome extrusion, and size characterization will be presented herein.
FAQs
Flow rate and viscosity are central process variables because they influence the diameter and organization of the resulting fibers. A change in either factor alters how the polymer moves through the spinneret or nozzle, while collection conditions further affect the final arrangement. Controlling these variables allows researchers to tune fiber architecture for different bioengineering requirements.
The solidification route determines how the extruded material becomes a stable fiber. Depending on the polymer system, this may occur through cooling, solvent removal, or chemical cross-linking. Each route provides a different processing condition for converting the flowing material into a usable structure, so the selected approach must match the material and intended biological application.
The spinneret or nozzle provides the passage through which the polymer melt or solution is formed into a continuous fiber. Its use supports control over fiber dimensions and organization when combined with regulated flow and collection conditions. This control is important for creating architectures that can be tailored to specific tissue-engineering or biomimetic designs.
Organized fibers create a structured architecture that can guide how cells interact with an engineered construct. In bioengineering, this arrangement may support cell attachment and directional growth, helping reproduce selected features of biological tissues. The ability to adjust organization therefore connects manufacturing conditions with the functional design of engineered tissue environments.
Fabrication requires coordinated control of polymer viscosity, flow rate, solidification conditions, and collection behavior. Researchers also select whether the material is processed as a melt or solution and whether cooling, solvent removal, or chemical cross-linking provides stabilization. Managing these factors together helps produce fibers with the intended diameter and organization rather than treating each variable independently.
Extruded fibers can be incorporated into tissue-engineering scaffolds, wound dressings, drug-delivery systems, and other biomimetic constructs. Their architecture can be adjusted to support biological interactions or to provide properties suited to a particular application. This versatility makes the technique relevant wherever continuous, organized biomaterial structures are needed for engineered biological systems.
The technique provides tunable fiber architectures that can be tailored to biological applications. These structures may support cell attachment and directional growth, while their organization contributes to biomimetic constructs designed for engineered tissues. Consequently, fiber extrusion links material processing with the creation of tissue environments whose structural properties are selected for a specific bioengineering purpose.