Laser Activated Adhesive

Laser activated adhesive is a bonding material whose adhesion is initiated or strengthened by focused laser energy, allowing precise control over when and where bonding occurs. In bioengineering, a light-absorbing component converts selected laser wavelengths into localized heat or photochemical energy, triggering adhesive curing, softening, or interfacial bonding while limiting exposure of surrounding tissue or materials. This spatial and temporal control supports applications such as wound closure, tissue repair, implant fixation, and fabrication of biomedical devices. By reducing the need for mechanical clamps or broadly applied chemical treatments, laser activation can improve placement accuracy and enable minimally invasive approaches to joining biological and engineered surfaces.

Laser Activated Adhesive - Related Videos

Research

JoVE Journal - Bioengineering

A Chitosan Based, Laser Activated Thin Film Surgical Adhesive, 'SurgiLux': Preparation and Demonstration

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Cited by 32 •

2012

The fabrication of a novel, flexible thin film surgical adhesive from FDA approved ingredients, chitosan and indocyanine green is described. Bonding of this adhesive to collagenous tissue through a simple activation process with a low-powered infra-red laser is demonstrated.

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Cited by 21 •

2014

Static adhesion assay is a powerful tool that can be used to model the interactions between T lymphocytes and other cell types. Interactions are generated by injecting labeled T cells into wells coated with adhesion molecules, while a plate reader is used to quantify the number of adherent cells following serial washes.

Measurement of Tension Release During Laser Induced Axon Lesion to Evaluate Axonal Adhesion to the Substrate at Piconewton and Millisecond Resolution

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Cited by 1 •

2013

We measured the tension release in an axon that was partially lesioned with a laser dissector by simultaneous force spectroscopy measurement performed on an optically-trapped probe adhered to the membrane of the axon. The developed experimental protocol evaluates the axon adhesion to the culture substrate.

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

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Cited by 3 •

2016

This flow adhesion assay provides a simple, high impact model of T cell-epithelial cell interactions. A syringe pump is used to generate shear stress, and confocal microscopy captures images for quantification. The goal of these studies is to effectively quantify T cell adhesion using flow conditions.

Cytoskeleton and Focal Adhesion Organization Assay: An Immunofluorescence-based Method to Study Cell Adhesion and Spreading on Substrates

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2023

This video describes the technique of studying the cytoskeleton and focal adhesions in primary human colon cancer cells to understand its variations depending on substrate rigidity. This culture of cancer cells on soft and hard substrates allows various downstream biophysical measurements for cancer prognosis.

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