Molecular Sensors
Molecular Sensors - Related Videos
09:14
Glovebox and Impurity Sensors
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2023
Source: Tamara M. Powers, Department of Chemistry, Texas A&M University The glovebox provides a straightforward means to handle air- and moisture-sensitive solids and liquids. The glovebox is what it sounds like: a box with gloves attached to one or more sides, which allows the user to perform manipulations within the glovebox under an inert atmosphere. For manipulations under inert atmospheres, chemists can choose between Schlenk or high-vacuum techniques and a glovebox. Schlenk and...
09:30
Bacterial Detection & Identification Using Electrochemical Sensors
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Cited by 6 •
2013
We describe an electrochemical sensor assay method for rapid bacterial detection and identification. The assay involves a sensor array functionalized with DNA oligonucleotide capture probes for ribosomal RNA (rRNA) species-specific sequences. Sandwich hybridization of target rRNA with the capture probe and a horseradish peroxidase-linked DNA oligonucleotide detector probe produces a measurable amperometric current.
06:54
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Cited by 3 •
2013
To demonstrate MR cancer molecular imaging with a small peptide targeted MRI contrast agent specific to clotted plasma proteins in tumor stroma in a mouse prostate cancer model.
07:13
Nanostructured Ag-zeolite Composites as Luminescence-based Humidity Sensors
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Cited by 9 •
2016
A protocol for the synthesis of moisture-responsive luminescent Ag-zeolite composites is described in this report.
10:23
Glutamine Flux Imaging Using Genetically Encoded Sensors
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Cited by 7 •
2014
This article will demonstrate how to monitor glutamine dynamics in live cells using FRET. Genetically encoded sensors allow real-time monitoring of biological molecules at a subcellular resolution. Experimental design, technical details of the experimental settings, and considerations for post-experimental analyses will be discussed for genetically encoded glutamine sensors.
FAQs
The receptor determines which analyte a sensor can recognize. Antibodies, nucleic acids, enzymes, and engineered proteins provide different molecular recognition elements that bind particular targets. This binding behavior establishes selectivity, while the sensor’s transduction system converts the recognition event into a measurable response. In bioengineering, receptor selection therefore shapes what biological or chemical information the device can monitor.
Binding triggers a change in a measurable property associated with the sensor. Depending on the design, that change may appear as altered fluorescence, electrical current, mass, or another readable signal. The transduction step connects molecular-scale recognition with an analytical output, allowing researchers to monitor target molecules rather than observing the binding event directly.
Molecular sensors can report recognition through several signal modes, including fluorescence, electrical current, mass, and other measurable properties. These outputs give designers flexibility when developing devices for biological or chemical systems. The selected signal modality also affects how the sensor can be incorporated into analytical platforms, including systems intended for miniaturization or portable use.
Recognition elements provide target specificity, while the transduction mechanism produces a signal that can be measured with suitable analytical hardware. Together, these features support sensitivity to biological or chemical changes and allow sensor designs to become smaller. Bioengineering uses this combination to develop portable diagnostic platforms and integrated systems for monitoring cells, tissues, and other complex biological settings.
A typical analysis begins when the target analyte encounters the sensor’s recognition element. If binding occurs, the interaction produces a change in fluorescence, electrical current, mass, or another measurable property. The resulting signal is then read as evidence of the target’s presence or behavior. This sequence links molecular recognition to practical analysis of biological or chemical systems.
In disease diagnosis, these devices can detect molecular information relevant to biological samples and support portable diagnostic platforms. During drug development, they can help monitor molecular interactions or changes associated with experimental systems. Their value comes from combining selective recognition with measurable outputs, enabling analytical measurements that contribute to biotechnology research and personalized medicine.
Environmental monitoring can use these devices to detect and measure molecules in chemical systems, while real-time analysis applies them to cells and tissues. Their readable signals allow changes to be followed through analytical measurements rather than relying only on endpoint observations. Miniaturized and integrated formats are especially relevant when monitoring must occur in portable or biologically connected systems.