Particle Adhesion
Particle Adhesion - Related Videos
01:14
Adhesion
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2019
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules. Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
09:52
Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks
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Cited by 10 •
2014
Flow chambers used in adhesion experiments typically consist of linear flow paths and require multiple experiments at different flow rates to generate a shear adhesion map. SynVivo-SMN enables the generation of shear adhesion map using a single experiment utilizing microliter volumes resulting in significant savings in time and consumables.
07:40
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Cited by 3 •
2016
This flow adhesion assay provides a simple, high impact model of T cell-epithelial cell interactions. A syringe pump is used to generate shear stress, and confocal microscopy captures images for quantification. The goal of these studies is to effectively quantify T cell adhesion using flow conditions.
03:37
Subatomic Particles
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2020
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom. The Discovery of the Electron The first clue about the subatomic structure came at the end of the 19th century when J.J. Thomson discovered the electron using a cathode ray tube. This apparatus consisted of a sealed glass...
06:44
Creation of Abdominal Adhesions in Mice
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Cited by 9 •
2016
Abdominal adhesions that form after surgery are a major cause of pain, infertility, and hospitalization and reoperation for small bowel obstruction. Our surgical procedure for creating abdominal adhesions in mice is a reliable tool to study the mechanisms underlying the formation of adhesions.
FAQs
Attachment becomes persistent when the combined attractive interactions at the interface exceed both repulsive interactions and forces produced by the surrounding fluid. Van der Waals forces act across closely separated surfaces, while electrostatic interactions depend on surface charge and hydrophobic effects favor some water-avoiding contacts. Specific ligand-receptor binding adds molecular recognition, which can make adhesion selective rather than purely physical.
Surface chemistry and wettability strongly influence whether a particle remains associated with a biomaterial or cell. Changing the chemistry can alter electrostatic attraction, hydrophobic effects, and the availability of ligand-receptor interactions. Particle size also matters because it changes interfacial contact and transport behavior. These variables are therefore considered together when optimizing adhesion for delivery, sensing, or tissue-engineering systems.
Flow conditions determine whether an attached particle stays in place or is removed. Even favorable surface interactions may not withstand fluid-induced detachment when transport conditions become more demanding. In a microfluidic device, adhesion must therefore be interpreted alongside particle movement and local flow, rather than treated as a fixed property of the particle alone. This distinction helps explain differences between static and flowing systems.
An adhesion study can compare particles or surfaces while varying particle size, surface chemistry, wettability, and flow conditions. Researchers then examine how these changes affect attachment and retention under the relevant engineered or biological setting. This comparative approach separates the contribution of interfacial interactions from fluid-driven removal and identifies conditions that improve performance without assuming that one surface design suits every application.
In drug-delivery research, adhesion analysis helps determine how carriers interact with cells. Surface properties and binding interactions can be adjusted to favor retention or more selective association, while flow conditions indicate whether carriers may remain near a target interface. The resulting design information supports targeted delivery and particle-based therapies by linking carrier behavior to the conditions encountered in a biological system.
Bioengineering applications extend beyond delivery. Adhesive behavior can help explain particle recruitment or retention in biomaterials, improve biosensor sensitivity by supporting particle capture at an interface, and guide the use of microparticles in microfluidic devices. In tissue engineering, controlling adhesion can influence how particles are retained within material environments. Across these uses, the desired outcome is reliable particle placement and performance.