Pdms Fluidic Chip

A PDMS fluidic chip is a miniaturized device made from polydimethylsiloxane that directs and manipulates small volumes of liquid through patterned microchannels. Fabricated by molding PDMS against a microscale template and bonding it to a substrate, the chip uses channel geometry, surface properties, and pressure-driven or capillary flow to control transport and mixing. In bioengineering, PDMS fluidic chips support cell culture, biochemical assays, tissue models, and lab-on-a-chip systems while requiring minimal sample and reagent volumes. Their optical transparency, flexibility, and rapid prototyping make them valuable for studying biological processes and developing compact diagnostic platforms.

Pdms Fluidic Chip - Related Videos

Research

JoVE Journal - Bioengineering

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

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2025

Here we present a protocol for constructing an organ-on-chip (OOC) system designed to mimic pneumonectomy. This system investigates the potential correlation between glycocalyx impairment and complications following pneumonectomy.

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

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Cited by 1 •

2016

We propose a simple self-assembly technique of silica colloidal nanoparticles to create a nanofluidic junction between two microchannels in polydimethylsiloxane (PDMS). Using this technique, a nanoporous bead membrane with a pore size down to ~45 nm was built inside a microchannel and applied to electrokinetic preconcentration of DNA samples.

Double Emulsion Generation Using a Polydimethylsiloxane (PDMS) Co-axial Flow Focus Device

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Cited by 8 •

2015

Microfluidic double emulsions generation typically involves devices with patterned wettability or custom-fabricated glass components. Here we describe the fabrication and testing of an all polydimethylsiloxane (PDMS) double emulsion generator that does not require surface treatment or complicated fabrication processes, and is capable of producing double emulsions down to 14 µm.

Research

JoVE Journal - Chemistry
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Microfluidic Pneumatic Cages: A Novel Approach for In-chip Crystal Trapping, Manipulation and Controlled Chemical Treatment

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Cited by 6 •

2016

Herein, we describe the fabrication and operation of a double-layer microfluidic system made of polydimethylsiloxane (PDMS). We demonstrate the potential of this device for trapping, directing the coordination pathway of a crystalline molecular material and controlling chemical reactions onto on-chip trapped structures.

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