Ultrasound Therapy
Ultrasound Therapy - Related Videos
01:28
Focused Ultrasound-Enhanced Nanoparticle Delivery in a Mouse Model for Tumor Therapy
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2025
Begin with an anesthetized tumor-bearing mouse and shave its head.Place it in an MRI scanner integrated with the focused ultrasound system.The initial MRI scan locates the brain tumor and nearby blood vessels.Inject a contrast agent intravenously, then administer fluorescently labeled nanoparticles coated onto gas-filled microbubbles.The contrast agent and microbubbles circulate and reach the brain.Apply focused ultrasound waves to the tumor site.The ultrasound causes the microbubbles to expand...
07:12
Diagnostic Ultrasound Imaging of Mouse Diaphragm Function
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Cited by 7 •
2014
Diagnostic ultrasound imaging has proven to be effective in diagnosing various respiratory diseases in human and animal subjects. We demonstrate a comprehensive ultrasound protocol utilized by Dr. Zuo's lab to analyze diaphragm kinetics specifically in mouse models. This is also a non-invasive research technique which can provide quantitative information on mouse respiratory muscle function.
05:05
Ultrasound Cyclo Plasty in Eyes with Glaucoma
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Cited by 17 •
2018
Glaucoma is a chronic disease with progressive degeneration of optic nerve fibers resulting in decreased visual field. Elevated intraocular pressure is considered the most important and the only treatable risk factor. This manuscript describes a simple, surgeon-friendly, non-incisional technique, named Ultrasound Cyclo Plasty, for reducing intraocular pressure in glaucoma patients.
10:53
A Novel Application of Musculoskeletal Ultrasound Imaging
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Cited by 14 •
2013
We describe a new ultrasound-based vector tissue Doppler imaging technique to measure muscle contraction velocity, strain and strain rate with sub-millisecond temporal resolution during dynamic activities. This approach provides complementary measurements of dynamic muscle function and could lead to a better understanding of mechanisms underlying musculoskeletal disorders.
03:10
Treatment of Brain Tumors in a Mouse Model Using Sonodynamic Therapy
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2025
Source: Mess, G., et al. Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System. J. Vis. Exp. (2023)This video demonstrates a protocol for performing sonodynamic therapy on a brain tumor in a mouse model using magnetic resonance-guided focused ultrasound (MRgFUS). A sonosensitizer precursor is administered prior to treatment, which accumulates in tumor cells and is activated by focused ultrasound to produce reactive...
FAQs
Tissue absorption converts part of the acoustic energy into localized heat. The resulting temperature pattern depends on how energy is distributed as waves travel through the tissue, so frequency, intensity, and exposure time become important control variables. Bioengineers adjust these settings to concentrate heating at the intended depth while limiting unnecessary energy deposition in nearby tissue.
Pressure variations can create mechanical effects that differ from heating. Acoustic streaming refers to fluid movement driven by the sound field, while cavitation describes effects associated with oscillating or forming bubbles. These interactions can alter the local tissue environment and support therapeutic strategies such as tissue healing or targeted drug delivery when treatment conditions are appropriately controlled.
These parameters influence how deeply energy reaches tissue, how strongly it interacts with biological structures, and how long the tissue experiences the acoustic field. Transducer design also shapes energy distribution. In bioengineering, coordinated adjustment of these variables helps match treatment delivery to the intended target and supports safety by reducing unwanted effects outside the treatment region.
Treatment begins with electrical energy supplied to a transducer, which converts that input into acoustic waves. The waves propagate through biological tissue, where absorption and pressure variations produce the intended interactions. A practical workflow therefore links transducer selection with control of frequency, intensity, and exposure time, allowing the delivered energy to be directed toward a chosen therapeutic effect.
The approach is relevant when therapeutic energy must reach biological tissue without an invasive procedure. Its reported uses include rehabilitation, tissue healing, and targeted drug delivery. These applications rely on different combinations of localized heating and mechanical effects, so parameter selection and transducer design must be matched to the desired biological outcome rather than treated as interchangeable settings.
Focused ultrasound concentrates acoustic energy in a selected region, enabling treatment of abnormal tissue while limiting effects on surrounding areas. This capability makes it relevant to procedures that require spatially controlled energy delivery. Bioengineers refine transducer design and operating parameters to control the focal distribution, treatment depth, and balance between therapeutic action and tissue protection.