Cancer Risk
Cancer Risk - Related Videos
09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Cited by 61 •
2010
Our protocol describes how to dissect the rat abdominal mammary gland and how to prepare mammary gland whole mounts. It also describes how to analyze mammary gland morphology using three end-points (number of terminal end buds, epithelial elongation and differentiation) and to use these results to predict mammary cancer risk in rats which were exposed to dietary modifications in utero or during prepuberty.
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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2025
Overtreatment is often administered to patients with low-risk prostate cancer; super-active surveillance can help avoid such overtreatment.
19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Cited by 40 •
2014
The NICU Network Neurobehavioral Scale (NNNS) was developed as an assessment for the at-risk infant. The purpose of this article is to describe the NNNS, provide video examples of the NNNS procedures and discuss the ways in which the exam has been used.
01:35
Types of Risk: Systematic Risk
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2024
Systematic risk is inherent to the market and reflects the impact of economic, financial, and geopolitical factors. It affects the entire market rather than specific stocks or industries. This type of risk is unavoidable and cannot be mitigated through diversification. Market risk refers to the possibility that the overall stock market will decline, impacting the value of all investments. This risk is often driven by macroeconomic factors such as economic recessions, financial crises, or global...
01:30
Types of Risk: Unsystematic Risk
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2024
Unsystematic risk refers to the uncertainty associated with individual companies or specific sectors rather than the entire stock market or economy. There are four main types of unsystematic risks: Business risk involves the operational challenges within a company. These risks stem from factors such as production issues, supply chain disruptions, or changes in consumer preferences. For example, if a company faces a significant problem in its supply chain, its stock prices might drop. This risk...
FAQs
Genetic susceptibility can make some individuals more vulnerable to changes caused by environmental exposures, while exposure-related DNA damage can add cellular disruption. Their effects are considered together rather than in isolation because cancer development can reflect several interacting influences. This combined view helps identify which factors may be preventable or manageable and supports more tailored risk evaluation.
Genes that regulate cell growth, DNA repair, and programmed cell death act as safeguards against abnormal cellular behavior. If mutations disrupt these functions, damaged or abnormal cells may survive and multiply instead of being controlled or eliminated. Examining these pathways gives biologists a mechanistic way to connect genetic changes with tumor development and study how cancers arise.
An inherited mutation is part of a person's genetic susceptibility, whereas DNA damage associated with environmental exposure represents another route to disruption. Cancer risk assessment considers both because they can contribute to changes in growth control, repair, or programmed cell death. Distinguishing these contributors helps researchers and clinicians evaluate whether risk may be reduced, managed, or addressed through tailored counseling.
Assessment draws on personal history, family history, environmental exposures, lifestyle information, and genetic information. These sources provide complementary perspectives: history can reveal patterns, exposure and lifestyle data can identify potentially preventable or manageable influences, and genetic information can indicate susceptibility. Combining them supports a more individualized interpretation than relying on any single factor alone.
Risk information can help guide screening strategies toward the needs of different individuals or populations. It also supports patient counseling by clarifying which influences may be preventable or manageable and by placing inherited, environmental, lifestyle, and genetic information in context. The goal is to use these factors to inform prevention and support decisions suited to the person's risk profile.
Studying cancer risk connects molecular events with the broader process of tumor formation. Researchers can examine how DNA damage and mutations affect growth regulation, DNA repair, and programmed cell death, then compare how inherited susceptibility and external influences contribute across populations. This work supports research into how tumors arise and how prevention approaches might be tailored to different populations.