Cell Type Conversion
Cell Type Conversion - Related Videos
02:08
Gene Conversion
0 Views •
2020
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
02:08
Gene Conversion
0 Views •
2023
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
13:58
Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
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Cited by 38 •
2015
Generation of induced pluripotent stem cells provides fascinating prospects for the derivation of autologous transplants. However, progression through a pluripotent state and laborious re-differentiation still hinders clinical translation. Here we describe the derivation of adult human fibroblasts and their direct conversion into induced neural progenitor cells and the subsequent differentiation into neural lineages.
08:45
Epigenetic Conversion as a Safe and Simple Method to Obtain Insulin-secreting Cells from Adult Skin Fibroblasts
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Cited by 9 •
2016
Here, a new method that allows the conversion of adult skin fibroblasts into insulin-secreting cells is presented. This technique is based on epigenetic conversion, does not involve the use of retroviral vectors nor the acquisition of a stable pluripotent state. It is therefore highly promising for translational medicine applications.
01:36
Conversion of Units
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2023
Sometimes, there is a need to convert from one unit to another one. For instance, reading a cookbook in which quantities are expressed in units of liters or ounces may require conversion of quantities to cups. Or, when looking up directions on how to get to a location, we may be interested to know how many miles we are going to walk. In this case, we would have to convert units of feet or meters to miles. The first step in the unit conversion is to list the given units and the units required...
FAQs
A successful conversion requires coordinated regulatory changes rather than activation of a single marker. Lineage-specific transcription factors help initiate the gene-expression program of the target cell, while suppression of the starting cell’s existing program prevents competing identity signals from dominating. Together, these changes redirect cellular identity and reveal how specialized states are maintained.
A mature cell already maintains a stable specialized state through its existing cellular programs. Suppressing those programs helps reduce the influence of the original identity while new lineage-specific factors become active. This balance is central to understanding how cells move between differentiated states and why cellular plasticity is an important biological property.
Epigenetic remodeling changes chromatin regulation during the transition between cell identities. It can help coordinate the activation of genes associated with the new lineage and the suppression of programs linked to the former identity. Studying these chromatin changes connects the observable shift in cellular identity with the gene-regulatory processes that produce and maintain it.
Direct reprogramming provides an approach for examining how one mature cellular identity can be redirected toward another. Researchers use it to investigate the regulatory changes associated with conversion without limiting their studies to normal developmental progression. This makes the approach useful for analyzing cellular plasticity and the mechanisms that establish specialized cell states.
In developmental biology, conversion studies help clarify how cell identities are established and maintained. In disease research, related approaches can support the creation of cellular models for examining disease-relevant states. These applications allow researchers to connect changes in gene regulation and chromatin with questions about normal development, altered cellular identity, and disease biology.
Conversion approaches can generate specialized cells for tissue repair research, making cellular identity changes relevant beyond basic biology. They also help researchers evaluate how controlled changes in gene regulation might support future regenerative medicine strategies. The research focus is on understanding and directing cell plasticity, rather than assuming that every conversion will produce a clinically useful tissue.