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Neuroscience

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Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
 

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Article doi: 10.3791/52831
July 29th, 2015

Summary July 29th, 2015

Generation of induced pluripotent stem cells provides fascinating prospects for the derivation of autologous transplants. However, progression through a pluripotent state and laborious re-differentiation still hinders clinical translation. Here we describe the derivation of adult human fibroblasts and their direct conversion into induced neural progenitor cells and the subsequent differentiation into neural lineages.

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