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Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

15,301 Views

13:58 min

July 29, 2015

DOI:

13:58 min
July 29, 2015

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Summary

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Generation of induced pluripotent stem cells provides fascinating prospects for the derivation of autologous transplants. However, progression through a pluripotent state and laborious re-differentiation still hinders clinical translation. Here we describe the derivation of adult human fibroblasts and their direct conversion into induced neural progenitor cells and the subsequent differentiation into neural lineages.

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