Endocardium
Endocardium - Related Videos
10:33
Local Field Fluorescence Microscopy: Imaging Cellular Signals in Intact Hearts
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Cited by 8 •
2017
In the heart, molecular events coordinate the electrical and contractile function of the organ. A set of local field fluorescence microscopy techniques presented here enables the recording of cellular variables in intact hearts. Identifying mechanisms defining the cardiac function is critical in understanding how the heart works under pathological situations.
01:27
Anatomy of the Heart
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2019
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
10:28
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Cited by 21 •
2015
Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.
07:46
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
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Cited by 13 •
2012
Experimental rat endocarditis model due to methicillin-resistant S. aureus.
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Cited by 34 •
2013
This article describes procedures for implanting a novel hydrogel in failing hearts and quantifying its effect on left ventricular wall stress and function. These procedures have been successfully applied in dogs and humans.
FAQs
Endocardial function depends on cooperation between its endothelial lining and supporting connective tissue. The endothelial cells form the blood-facing interface, while the connective tissue provides structural support. Together, these components maintain a smooth boundary over cardiac surfaces, helping limit friction during blood movement and preserving separation between circulating blood and the myocardium.
Mechanical forces and circulating signals make the endocardium responsive rather than purely passive. Changes affecting the blood-facing surface can influence communication between blood and cardiac tissues, while physical forces provide information about conditions within the chambers. This responsiveness connects local cardiac structure with changing flow and circulating environments.
At the valves, the endocardium does more than provide a lining. Its contribution to valve structure places it at a site where tissue organization and blood movement must work together. Studying this interface can therefore clarify how altered valve tissue relates to disturbed flow and to diseases involving the cardiac valves.
Examining its organization and responses provides a way to connect microscopic cardiac structure with blood-flow regulation, barrier function, and tissue communication. Researchers can use this perspective to interpret how the heart wall interacts with blood and how changes at that interface may relate to broader cardiovascular problems.
Endocardial abnormalities matter clinically because this tissue participates in barrier function, flow regulation, valve structure, and communication with cardiac tissues. Studying those roles helps place endocarditis and thrombosis in a shared cardiovascular context, while also linking tissue changes to valve disease and other conditions affecting cardiac health.
Its study spans normal and abnormal heart biology. Because the tissue responds to mechanical forces and circulating signals, it offers a context for examining how cardiac structures interact with their environment. This is relevant to development, valve disease, endocarditis, thrombosis, and broader cardiovascular health research.