Enteric Nervous System

The enteric nervous system is the extensive network of neurons and glial cells embedded in the gastrointestinal tract, where it regulates digestive functions and coordinates communication between the gut and the rest of the nervous system. Organized mainly into the myenteric and submucosal plexuses, it receives sensory information from the intestinal environment and uses neural circuits and neurotransmitters to control smooth-muscle contractions, secretion, blood flow, and local reflexes. Although it operates with substantial independence, autonomic signals can modify its activity. Studying the enteric nervous system helps explain gut motility, digestive physiology, and disorders such as constipation, irritable bowel syndrome, and other conditions involving gut-brain communication.

Enteric Nervous System - Related Videos

Research

JoVE Journal - Neuroscience
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In Situ Ca2+ Imaging of the Enteric Nervous System

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Cited by 24 •

2015

The enteric nervous system (ENS) is a network of neurons and glia located in the gut wall that controls intestinal reflexes. This protocol describes methods for recording the activity of enteric neurons and glia in live preparations of ENS using Ca2+ imaging.

Education

JoVE Core - Pharmacology

Physiology of Enteric Nervous System and Gut Health

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2024

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...

Enteric Nervous System: Regulation of GI Motor Activity

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2024

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs. During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

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Cited by 37 •

2010

Parkinson's disease has been related to the exposure to pesticides. Here we show a method to deliver pesticides using a gastric tube at the desired concentration and a method to analyze their effect in alpha-synuclein accumulation in the enteric nervous system.

Immunostaining to Visualize Murine Enteric Nervous System Development

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Cited by 3 •

2015

The enteric nervous system is formed by neural crest cells that proliferate, migrate and colonize the gut. Neural crest cells differentiate into neurons with markers specific for their neurotransmitter phenotype. This protocol describes a technique for dissecting, fixing and immunostaining of the murine embryonic gastrointestinal tract to visualize enteric nervous system neurotransmitter expression.

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