Fascial System

The fascial system is a continuous network of connective tissues that surrounds, separates, supports, and connects muscles, organs, nerves, blood vessels, and other body structures. Its extracellular matrix, rich in collagen and elastin, gives fascia tensile strength and flexibility, while hydrated layers allow tissues to glide and transmit mechanical forces across regions. In biology, studying fascia helps explain how body compartments maintain organization, how movement-related loads travel through tissues, and how changes in tissue structure may affect mobility and function. Fascial anatomy also informs research on musculoskeletal health, injury, surgical approaches, and tissue remodeling.

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Research

JoVE EoE - Skin Cancer

Patient-derived Xenograft Modeling: A Technique to Generate Melanoma Mouse Models

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2023

In this video, human-derived melanoma cells are implanted subcutaneously into the flank region of an immunocompromised mouse. The PDX model allows preclinical investigation of melanoma cells that better recapitulate the tumor heterogeneity and melanoma aggressiveness observed in in vivo conditions.

Clinical Efficacy of Ultrasound-Assisted Scoliosis-Specific Exercise in Mild-Grade Adolescent Idiopathic Scoliosis

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2025

Here, we present a protocol to evaluate ultrasound-assisted scoliosis-specific exercise in adolescents with mild idiopathic scoliosis, with participants randomly assigned to a training program conducted three times per week for three months, followed by a three-month observation period, providing real-time feedback on intercostal muscle activation and breathing control.

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

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2025

This prospective study evaluated the implementation of a novel, single-port, robotic platform in oncoplastic breast-conserving surgery for malignant lesions. The primary endpoint focused on technical success, defined as the achievement of tumor-free resection margins confirmed by intraoperative frozen-section histopathology, with secondary assessment of aesthetic outcomes and life quality score of patients.

Reproducible Mouse Sciatic Nerve Crush and Subsequent Assessment of Regeneration by Whole Mount Muscle Analysis

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Cited by 59 •

2012

In this report we describe a method to crush mouse sciatic nerve. This method uses readily available hemostatic forceps and easily and reproducibly produces complete sciatic nerve crush. In addition, we describe a method to prepare muscle whole mounts suitable for analysis of nerve regeneration after sciatic nerve crush.

Ex vivo Culturing of Whole, Developing Drosophila Brains

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Cited by 16 •

2012

This article describes a method by which one can mimic in vivo development of the Drosophila mushroom body in an ex vivo culture system.

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