Fibrous Cardiac Skeleton

The fibrous cardiac skeleton is a network of dense connective tissue that supports the heart’s valves and anchors cardiac muscle, helping maintain the shape and mechanical integrity of the heart. Its collagen-rich rings and connective tissue sheets provide structural attachment points while electrically insulating the atria from the ventricles, so impulses normally pass between them through the atrioventricular conduction system. In biology and cardiovascular research, this framework is important for understanding valve function, coordinated cardiac contraction, and the organization of the conduction pathway. Changes in its structure can affect heart mechanics and electrical signaling, making it relevant to studies of cardiac development and disease.

Fibrous Cardiac Skeleton - Related Videos

Education

JoVE Core - Molecular Biology

Globular and Fibrous Proteins

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2020

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities. Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

Research

JoVE Journal - Biology

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton

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Cited by 18 •

2016

The branchial skeleton, including gill rakers, pharyngeal teeth, and branchial bones, serves as the primary site of food processing in most fish. Here we describe a protocol to dissect and flat-mount this internal skeleton in threespine sticklebacks. This method is also applicable to a variety of other fish species.

Carbon Skeletons

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2026

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...

Fibrous Proteins

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2023

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...

Skeleton and Calcium Homeostasis

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2023

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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