Heart Function
Heart Function - Related Videos
04:52
Ex Situ Heart Perfusion: A Technique to Preserve Isolated Porcine Heart Function
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2025
This video describes an ex situ technique for preserving an isolated porcine heart by perfusing it with an oxygenated nutrient-rich perfusate solution. The technique allows the comprehensive evaluation of cardiac performance under physiological conditions.
02:08
Viral Gene Delivery in the Mouse Heart for Evaluating Gene Effects on Heart Function
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2026
Source: Lu, A., et al. Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk. J. Vis. Exp. (2022)The video demonstrates a method for ultrasound-guided intramyocardial injection of a recombinant viral vector in a mouse model. This technique enables targeted gene delivery to the heart for studying the effects of transgene expression on cardiac function.
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Cited by 34 •
2013
This article describes procedures for implanting a novel hydrogel in failing hearts and quantifying its effect on left ventricular wall stress and function. These procedures have been successfully applied in dogs and humans.
09:37
Monitoring Heart Function in Larval Drosophila melanogaster for Physiological Studies
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Cited by 47 •
2009
We present various ways to monitor heart function in the larva of Drosophila for assessing questions dealing with the function of gap junctions, ion channel mutations, modulation of pacemaker activity and pharmacological studies.
11:38
Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
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Cited by 36 •
2010
Langendorff-mode isolated heart perfusion, in conjunction with 31P NMR spectroscopy, combines the fields of biochemistry and physiology into one experiment. The protocol allows for the dynamic measurement of high energy phosphate content and turnover in the heart while concurrently monitoring physiologic function. When performed correctly, this is a valuable technique in the assessment of cardiac energetics.
FAQs
Electrical coordination determines when cardiac muscle contracts. The sinoatrial node generates impulses that spread through the atria and then reach the ventricles, linking atrial and ventricular activity within the cardiac cycle. Studying this sequence helps biologists connect electrical signaling with the mechanical events that move blood through the circulation.
Pressure changes provide the operating signal for valve movement. As pressure changes during the cardiac cycle, valves open or close, preserving one-way blood flow rather than allowing backflow. This relationship is important when analyzing heart function because valve behavior must be interpreted alongside contraction and pressure changes, not as an isolated event.
Heart rate, blood pressure, and cardiac output offer complementary ways to study cardiovascular performance. In biology, these measures are examined within the cardiac cycle to evaluate how cardiac activity supports homeostasis. Considering them together provides a broader picture than focusing only on the electrical impulse or on individual muscle contractions.
A basic study of heart function follows the sequence from impulse generation to contraction, valve movement, and blood flow. Researchers can then examine the cardiac cycle alongside heart rate, blood pressure, and cardiac output. This organized workflow connects cellular electrical activity with circulation and with the body's need to maintain homeostasis.
Diagnostic testing can use heart-function measures to investigate how effectively circulation is being maintained. Pharmacology research uses the same biological framework to examine interventions, while treatment research focuses on restoring effective circulation. These applications make cardiac-cycle analysis relevant to both understanding cardiovascular disease and evaluating approaches intended to improve function.
Cardiovascular disease research depends on identifying where coordinated function may be disrupted. Electrical signaling, contraction, valve behavior, and circulation provide distinct aspects for investigation, while heart rate, blood pressure, and cardiac output supply broader functional context. Together, these areas help biology relate cardiac mechanisms to disease processes and possible treatments.