Genetic Inheritance

Genetic inheritance is the transmission of biological information from parents to offspring, shaping traits and contributing to variation within populations. It occurs when DNA sequences carried on chromosomes are copied and passed through reproductive cells, while meiosis separates allele combinations and fertilization reunites genetic material from two parents. Patterns such as dominant and recessive inheritance help explain observable traits, whereas mutation, recombination, and non-Mendelian interactions produce additional diversity. Studying genetic inheritance provides a foundation for understanding development, evolution, inherited disorders, genetic counseling, and modern research in medicine, agriculture, and biotechnology.

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JoVE Core - Biology

Chromosomal Theory of Inheritance

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2019

In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.” The mechanisms underlying Mendel’s observations—the basis of his laws of segregation and independent assortment—remained elusive. In the late 1800s,...

Inheritance of Chromatin Structures

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2020

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

Genomic Imprinting and Inheritance

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2020

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes. The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Non-nuclear Inheritance

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2020

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus. Mitochondria are present in both plants and animal cells. They are regarded as the “powerhouses” of eukaryotic cells because they break down...

Genetic Crosses

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2023

To dissect genetic processes or create organisms with novel suites of traits, scientists can perform genetic crosses, or the purposeful mating of two organisms. The recombination of parental genetic material in the offspring allows researchers to deduce the functions, interactions, and locations of genes. This video will examine how genetic crosses were influential in developing Mendel's three laws of inheritance, which form the basis of our understanding of genetics. One genetic crossing...

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