Growth Plate Cartilage
Growth Plate Cartilage - Related Videos
06:53
A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
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Cited by 22 •
2017
The growth plate is a cartilaginous region in children's long bones where longitudinal growth occurs. When injured, bony tissue can form and impair growth. We describe a rat model of growth plate injury that leads to bony repair tissue, allowing the study of repair mechanisms and growth plate regeneration strategies.
01:27
Growth of Cartilage and Bone Tissue
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2023
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
07:58
Tricolor Transgenic Murine Model for Studying Growth Plate Injury
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Cited by 2 •
2024
This protocol describes an improved mouse model for adolescent bone growth plate injuries. Using transgenic mice with tri-lineage fluorescent reporters for collagen types I, II, and X, the primary matrices associated with three different substrata of the growth plate, injury placement is guided by native fluorescence under the microscope.
12:37
3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
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Cited by 38 •
2015
Cartilage repair represents an unmet medical challenge and cell-based approaches to engineer human articular cartilage are a promising solution. Here, we describe three-dimensional (3D) biomimetic hydrogels as an ideal tool for the expansion and maturation of human articular chondrocytes.
13:06
Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
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Cited by 7 •
2012
Nanoparticles such as semiconductor quantum dots (QDs) can be used to create photoactivatable agents for anti-microbial or anti-cancer applications. This technique shows how to water-solubilize cadmium telluride (CdTe) QDs, conjugate them to an antibiotic, and perform a bacterial inhibition assay based upon growth curves and plate count.
FAQs
The zones coordinate a sequence of chondrocyte behaviors rather than functioning independently. Chondrocytes first proliferate, then enlarge, while the surrounding cells produce extracellular matrix. As cartilage becomes older, it calcifies and is progressively replaced by bone. This ordered progression connects cellular development with the lengthwise expansion of growing bones.
Extracellular matrix production supports the organized cartilage environment in which chondrocytes develop. As cells proliferate and enlarge, they contribute to a matrix that later undergoes calcification. The changing matrix therefore forms part of the transition from cartilage to bone, helping link cellular activity within the plate to skeletal growth through endochondral ossification.
Closure marks the point at which the growth plate no longer supports the same developmental sequence associated with lengthwise skeletal growth. Before closure, chondrocyte proliferation, enlargement, matrix production, calcification, and bone replacement occur in an ongoing pattern. Studying when this process ends helps relate tissue development to mature bone structure and final skeletal proportions.
Growth plate cartilage provides a tissue-level example of endochondral ossification, in which older cartilage is gradually replaced by bone. The process demonstrates how organized cellular changes can guide skeletal development rather than producing bone independently of a cartilage framework. It therefore connects chondrocyte biology, extracellular matrix changes, and the formation of growing bones.
Researchers can use growth plate cartilage to examine how normal skeletal growth is coordinated and how disruptions may affect height or skeletal proportions. Because the tissue contains sequential cellular and matrix changes, it offers a context for connecting altered development with growth disorders. Its study can also support broader understanding of cartilage behavior during skeletal development.
The growth plate is relevant because it demonstrates a coordinated cartilage-to-bone transition driven by developing chondrocytes and changing extracellular matrix. This developmental context can inform research on cartilage repair and regenerative approaches by identifying features of organized tissue development that may be important when investigating how cartilage is maintained, restored, or integrated with skeletal growth.