Mechanoreceptors

Mechanoreceptors are specialized sensory cells or nerve endings that detect mechanical forces, including touch, pressure, vibration, stretch, and movement, and convert them into neural signals. When physical deformation changes the tension or shape of mechanically gated ion channels, ion flow alters the receptor membrane potential; if the signal reaches threshold, sensory neurons generate action potentials that the nervous system interprets. In biology, mechanoreceptors support skin sensation, proprioception, hearing, balance, and regulation of internal organs, enabling organisms to respond to their environment and maintain coordinated movement. Studying these receptors informs research on sensory disorders, neural circuits, and biomimetic devices.

Mechanoreceptors - Related Videos

Research

JoVE EoE - Immunodiagnostics

The Effects of Shear Stress on Platelets Treated with Antibodies Against Mechanosensory Receptors

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2025

This video demonstrates the method to assess the impact of shear stress on platelets. Antibody treatment induces dissociation and conformational changes in mechanoreceptor complexes, activating the platelets and expressing markers on the surface. These markers are observed via immunostaining and flow cytometry.

Obtaining Somatosensory Stimulation-Related Signals from Orofacial Skin Stretching

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2025

This video demonstrates the recording of somatosensory stimulation-related signals through orofacial skin stretch using an electroencephalography (EEG) cap equipped with electrodes to monitor brain activity and a robotic device that produces the skin stretch.

Subcutaneous Trigeminal Nerve Stimulation to Relieve Neuropathic Facial Pain

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2025

Source: Jakobs, M., et al. Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain. J. Vis. Exp. (2017)This procedure demonstrates the implantation of subcutaneous electrodes for trigeminal nerve stimulation to treat neuropathic facial pain. The electrodes are tunneled subcutaneously from the affected facial region to an infraclavicular pocket, where they are connected to an internal pulse generator (IPG). The IPG delivers electrical stimulation, activating mechanoreceptor...

Education

JoVE Science Education - Clinical Skills

Sensory Exam

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2023

Source:Tracey A. Milligan, MD; Tamara B. Kaplan, MD; Neurology, Brigham and Women's/Massachusetts General Hospital, Boston, Massachusetts, USA A complete sensory examination consists of testing primary sensory modalities as well as cortical sensory function. Primary sensory modalities include pain, temperature, light touch, vibration, and joint position sense. Sensation of the face is discussed in the videos Cranial Nerves Exam I and II, as are the special senses of smell, vision, taste, and...

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