Mediastinum

The mediastinum is the central compartment of the thoracic cavity, separating the right and left pleural sacs and organizing vital structures between the sternum and vertebral column. Extending from the thoracic inlet to the diaphragm, it is commonly divided into superior and inferior regions; the inferior mediastinum includes anterior, middle, and posterior subdivisions, with the heart enclosed in the pericardium and the trachea, esophagus, great vessels, nerves, and lymphatics following defined anatomical pathways. Understanding these relationships supports interpretation of chest imaging, guides cardiothoracic procedures, and helps localize masses, inflammation, vascular abnormalities, and other diseases that can compress or displace mediastinal contents.

Mediastinum - Related Videos

Education

JoVE Science Education - Clinical Skills

Tube Thoracostomy

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2023

Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Tube thoracostomy (chest tube placement) is a procedure during which a hollow tube is inserted into the thoracic cavity for drainage of fluid or air. Emergency chest tube insertion is performed for definitive treatment of tension pneumothorax, traumatic hemothorax, large-volume pleural effusions, and empyemas. Irrespective of the cause of air and fluid accumulation in the pleural space, the...

Research

JoVE Journal - Immunology and Infection

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

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Cited by 14 •

2015

This report provides a detailed description of transplanting murine thymi from different aged donor mice under the kidney capsule of immunodeficient mouse recipients. The goal of this approach is to model T cell development and thymic selection events in vivo.

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome

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2026

Robotic-assisted pneumonectomy is safe and effective in the management of Vanishing Lung Syndrome, with reduced morbidity and faster recovery times.

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

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Cited by 3 •

2016

In these studies, we provide methodology for novel, neonatal, murine cardiac scaffolds for use in regenerative studies.

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

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Cited by 11 •

2016

We describe a method for the detection of tumor nodule development in the lungs of an adenocarcinoma mouse model using micro-computed tomography and its use for monitoring changes in nodule size over time and in response to treatment. The accuracy of the assessment was confirmed with end-point histological quantification.

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